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dc.contributor.authorBelet, N
dc.contributor.authorImdat, H
dc.contributor.authorYanik, F
dc.contributor.authorKucukoduk, S
dc.date.accessioned2020-06-21T15:43:50Z
dc.date.available2020-06-21T15:43:50Z
dc.date.issued2003
dc.identifier.issn0334-018X
dc.identifier.urihttps://hdl.handle.net/20.500.12712/21723
dc.descriptionWOS: 000186126200007en_US
dc.descriptionPubMed: 14594173en_US
dc.description.abstractObjective: Since preeclampsia causes placental insufficiency, it can be hypothesized that it decreases placental passage of thyroxine (T-4) from mother to infant and thus may deepen the transient hypothyroxinemia seen in preterm infants after birth. The aim of this study was to compare thyroid function tests of preterm infants born to preeclamptic mothers with placental insufficiency with preterm infants born to mothers without placental insufficiency. Methods: Thirty-one preterm infants born to preeclamptic mothers with placental insufficiency were included in the study (group I) and 31 preterm infants born to mothers without placental insufficiency were included as the control group (group II). Thyroid hormone levels were assayed from blood samples obtained from the women before birth and thereafter from the infants at delivery (cord) and on the 1(st), 3(rd), 7(th), and 21(st) days of life. Results: Cord blood triiodothyronine (T-3), free T-3 (FT3) and free thyroxine (FT4) levels in group I were lower than in group II, whereas thyrotropin (TSH) and thyroxine binding globulin (TBG) levels were higher. No statistical difference in hormone levels studied at postnatal 1(st), 3(rd), 7(th), and 21(st) day was found between the two groups. Conclusion: Low levels of thyroid hormones and high level of TSH in cord blood in premature infants born to preeclamptic mothers with placental insufficiency suggest intrauterine hypothyroidism. Increase in TSH and thyroid hormone concentrations after birth reveal that the hypothalamic-pituitary-thyroid axis is intact.en_US
dc.language.isoengen_US
dc.publisherFreund Publishing House Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpreterm infantsen_US
dc.subjectthyroid hormone concentrationsen_US
dc.subjectpreeclampsiaen_US
dc.subjectplacental insufficiencyen_US
dc.titleThyroid function tests in preterm infants born to preeclamptic mothers with placental insufficiencyen_US
dc.typearticleen_US
dc.contributor.departmentOMÜen_US
dc.identifier.volume16en_US
dc.identifier.issue8en_US
dc.identifier.startpage1131en_US
dc.identifier.endpage1135en_US
dc.relation.journalJournal of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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