dc.contributor.author | Yazici, M | |
dc.contributor.author | Demircan, S | |
dc.contributor.author | Durna, K | |
dc.contributor.author | Sahin, M | |
dc.date.accessioned | 2020-06-21T15:36:59Z | |
dc.date.available | 2020-06-21T15:36:59Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0910-8327 | |
dc.identifier.issn | 1615-2573 | |
dc.identifier.uri | https://doi.org/10.1007/s00380-004-0812-6 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12712/21116 | |
dc.description | WOS: 000229505900002 | en_US |
dc.description | PubMed: 15912304 | en_US |
dc.description.abstract | We evaluated whether there was any relation between myocardial injury and endothelin-1 (ET-1) levels, which has been suggested as a contributor to the progression of ischemic heart failure. One hundred and twenty-one patients with chronic ischemic heart failure and 37 healthy individuals were included in the study. Cardiac troponin-I (cTn-I) and ET-1 levels of all subjects were measured on admission. Echocardiographic evaluations were also performed. The positivity of cTn-I increased significantly as the severity changed from New York Heart Association (NHYA) Class I to IV ( P < 0.01). This was also true for quantitative cTn-I levels ( P < 0.05). The ET-1 levels of patients were higher than controls on admission ( P < 0.001). The ET-1 levels increased significantly upon the progression from NHYA Class I to IV ( P < 0.001). Moreover, patients with cTn-I positivity had higher ET-1 levels ( P < 0.05) and a lower ejection fraction ( P < 0.001). A negative correlation was found between ejection fraction and the ET-1 levels ( r = -0.312, P = 0.019). In patients with cTn-I positivity, the cTn-I levels showed a positive correlation with the ET-1 levels ( r = 0.328, P = 0.014) and a negative correlation with ejection fraction ( r = -0.671, P < 0.001). In chronic ischemic heart failure, an increase in ET-1 may exert an influence on the progression of cardiac failure by leading to myocardial injury which may be demonstrated by higher cTn-I levels. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.relation.isversionof | 10.1007/s00380-004-0812-6 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | chronic ischemic heart failure | en_US |
dc.subject | endothelin-1 | en_US |
dc.subject | myocardial injury | en_US |
dc.title | The relation between endothelin-1 levels and myocardial injury in chronic ischemic heart failure | en_US |
dc.type | article | en_US |
dc.contributor.department | OMÜ | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 95 | en_US |
dc.identifier.endpage | 99 | en_US |
dc.relation.journal | Heart and Vessels | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |