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dc.contributor.authorYazici, M
dc.contributor.authorDemircan, S
dc.contributor.authorDurna, K
dc.contributor.authorSahin, M
dc.date.accessioned2020-06-21T15:36:59Z
dc.date.available2020-06-21T15:36:59Z
dc.date.issued2005
dc.identifier.issn0910-8327
dc.identifier.issn1615-2573
dc.identifier.urihttps://doi.org/10.1007/s00380-004-0812-6
dc.identifier.urihttps://hdl.handle.net/20.500.12712/21116
dc.descriptionWOS: 000229505900002en_US
dc.descriptionPubMed: 15912304en_US
dc.description.abstractWe evaluated whether there was any relation between myocardial injury and endothelin-1 (ET-1) levels, which has been suggested as a contributor to the progression of ischemic heart failure. One hundred and twenty-one patients with chronic ischemic heart failure and 37 healthy individuals were included in the study. Cardiac troponin-I (cTn-I) and ET-1 levels of all subjects were measured on admission. Echocardiographic evaluations were also performed. The positivity of cTn-I increased significantly as the severity changed from New York Heart Association (NHYA) Class I to IV ( P < 0.01). This was also true for quantitative cTn-I levels ( P < 0.05). The ET-1 levels of patients were higher than controls on admission ( P < 0.001). The ET-1 levels increased significantly upon the progression from NHYA Class I to IV ( P < 0.001). Moreover, patients with cTn-I positivity had higher ET-1 levels ( P < 0.05) and a lower ejection fraction ( P < 0.001). A negative correlation was found between ejection fraction and the ET-1 levels ( r = -0.312, P = 0.019). In patients with cTn-I positivity, the cTn-I levels showed a positive correlation with the ET-1 levels ( r = 0.328, P = 0.014) and a negative correlation with ejection fraction ( r = -0.671, P < 0.001). In chronic ischemic heart failure, an increase in ET-1 may exert an influence on the progression of cardiac failure by leading to myocardial injury which may be demonstrated by higher cTn-I levels.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s00380-004-0812-6en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchronic ischemic heart failureen_US
dc.subjectendothelin-1en_US
dc.subjectmyocardial injuryen_US
dc.titleThe relation between endothelin-1 levels and myocardial injury in chronic ischemic heart failureen_US
dc.typearticleen_US
dc.contributor.departmentOMÜen_US
dc.identifier.volume20en_US
dc.identifier.issue3en_US
dc.identifier.startpage95en_US
dc.identifier.endpage99en_US
dc.relation.journalHeart and Vesselsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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