Effects of fluoride on C-reactive protein, adenosine deaminase, and ceruloplasmin in rabbit sera

Abstract

Twenty healthy 6-month-old male and female New Zealand rabbits with a mean body weight of 3.5 +/- 0.5 kg were fed a standard commercial rabbit diet and provided with water ad libitum containing 40 mg F/L for 70 days. Blood samples were obtained from each rabbit, and sera adenosine deaminase (ADA) activity and C-reactive protein (CRP) and ceruloplasmin (CP) levels were determined with the following results at the start, at day 35, and at day 70, respectively: ADA activity 9.56 +/- 0.66, 14.78 +/- 1.11, and 19.56 +/- 1.85 U/L; CRP level 18.1 +/- 2.6, 85.5 +/- 20.3, and 123 +/- 23.26 ng/mL; CP level 22.19 +/- 2.66,19.49 +/- 1.18, and 14.75 +/- 0.96 mg/dL. By days 35 and 70 significant increases in ADA activity and CRP levels had occurred, along with a significant decrease in the CP level. These results demonstrated that fluoride intoxication caused significant alterations in ADA, CRP, and CP in rabbit sera.