| dc.contributor.author | Kaya, Ahmet H. | |
| dc.contributor.author | Vlamings, Rinske | |
| dc.contributor.author | Tan, Sonny | |
| dc.contributor.author | Lim, Lee Wei | |
| dc.contributor.author | Magill, Peter J. | |
| dc.contributor.author | Steinbusch, Harry W. M. | |
| dc.contributor.author | Temel, Yasin | |
| dc.date.accessioned | 2020-06-21T15:13:25Z | |
| dc.date.available | 2020-06-21T15:13:25Z | |
| dc.date.issued | 2008 | |
| dc.identifier.issn | 0006-8993 | |
| dc.identifier.uri | https://doi.org/10.1016/j.brainres.2008.05.019 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12712/19243 | |
| dc.description | Sharp, Trevor/0000-0001-7434-9713; Lim, Lee Wei/0000-0001-6692-6285 | en_US |
| dc.description | WOS: 000258254300011 | en_US |
| dc.description | PubMed: 18565496 | en_US |
| dc.description.abstract | Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain. (C) 2008 Elsevier B.V. All rights reserved. | en_US |
| dc.description.sponsorship | Medical Research CouncilMedical Research Council UK (MRC); Parkinson's UKParkinson's UK [G-0716] | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Elsevier Science Bv | en_US |
| dc.relation.isversionof | 10.1016/j.brainres.2008.05.019 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Parkinson's disease | en_US |
| dc.subject | serotonin | en_US |
| dc.subject | dorsal raphe nucleus | en_US |
| dc.subject | subthalamic nucleus | en_US |
| dc.title | Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats | en_US |
| dc.type | article | en_US |
| dc.contributor.department | OMÜ | en_US |
| dc.identifier.volume | 1221 | en_US |
| dc.identifier.startpage | 93 | en_US |
| dc.identifier.endpage | 97 | en_US |
| dc.relation.journal | Brain Research | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
