Neuromyelitis Optica Spectrum Disorder in Sjogren's Syndrome

Abstract

Sjogren's syndrome is a slowly progressive autoimmune disease. Neurological involvement is seen in approximately 20-25% of all cases of Sjogren's syndrome - 87% in the peripheral nervous system and almost 13% in the central nervous system. Neuromyelitis Optica (NMO)-like clinical picture is quite rare in Sjogren's syndrome. We present clinical and radiological features mimicking NMO spectrum disorder in two patients who were diagnosed with Sjogren's syndrome after investigation. In such cases, the early diagnosis and treatment of Sjogren's syndrome is of great importance for the prognosis of the disease. (Archives of Neuropsychiatry 2011; 48: 221-3)