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dc.contributor.authorCeyhun, Saltuk Bugrahan
dc.contributor.authorAksakal, Ercument
dc.contributor.authorEkinci, Deniz
dc.contributor.authorErdogan, Orhan
dc.contributor.authorBeydemir, Sukru
dc.date.accessioned2020-06-21T14:29:27Z
dc.date.available2020-06-21T14:29:27Z
dc.date.issued2011
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.urihttps://doi.org/10.1007/s12011-011-9068-z
dc.identifier.urihttps://hdl.handle.net/20.500.12712/16902
dc.descriptionCeyhun, Saltuk Bugrahan/0000-0003-1808-5041; ERDOGAN, Orhan/0000-0001-8908-7293en_US
dc.descriptionWOS: 000298192900077en_US
dc.descriptionPubMed: 21547398en_US
dc.description.abstractThe present research aims to evaluate the effects of cobalt and zinc exposure of rainbow trout (Oncorhynchus mykiss) on metallothioneins and cytocrome P450. Mature rainbow trouts were exposed to 10 mg/L CoCl2.6H(2)O and 1 mg/L ZnSO4.7H(2)O. After 6, 12, 24, and 48 h of treatment, expressions of muscle MT-A, MT-B, and CYP P4501A1 mRNAs were measured by means of quantitative real-time polymerase chain reaction. During the exposure experiments, no mortalities occurred. We observed that expression levels of all genes increased with exposure time. Since the organism has not learned how to completely dispose of heavy metals and tends to bioaccumulate them, our results indicate that cobalt and zinc exposure may result in accumulation of the non-eliminated metals which may lead to fish death.en_US
dc.language.isoengen_US
dc.publisherHumana Press Incen_US
dc.relation.isversionof10.1007/s12011-011-9068-zen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGene expressionen_US
dc.subjectMetallothioneinen_US
dc.subjectCytocrome P450 1Aen_US
dc.subjectHeavy metalen_US
dc.titleInfluence of Cobalt and Zinc Exposure on mRNA Expression Profiles of Metallothionein and Cytocrome P450 in Rainbow Trouten_US
dc.typearticleen_US
dc.contributor.departmentOMÜen_US
dc.identifier.volume144en_US
dc.identifier.issue01.Maren_US
dc.identifier.startpage781en_US
dc.identifier.endpage789en_US
dc.relation.journalBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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