| dc.contributor.author | Yildirim, Tuba | |
| dc.contributor.author | Bilgin, Kemal | |
| dc.contributor.author | Ciftci, Gonul Yenilmez | |
| dc.contributor.author | Ecik, Esra Tanriverdi | |
| dc.contributor.author | Senkuytu, Elif | |
| dc.contributor.author | Uludag, Yildiz | |
| dc.contributor.author | Kilic, Adem | |
| dc.date.accessioned | 2020-06-21T14:27:44Z | |
| dc.date.available | 2020-06-21T14:27:44Z | |
| dc.date.issued | 2012 | |
| dc.identifier.issn | 0223-5234 | |
| dc.identifier.issn | 1768-3254 | |
| dc.identifier.uri | https://doi.org/10.1016/j.ejmech.2012.03.018 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12712/16520 | |
| dc.description | Senkuytu, Elif/0000-0002-3579-8062 | en_US |
| dc.description | WOS: 000304291600020 | en_US |
| dc.description | PubMed: 22483088 | en_US |
| dc.description.abstract | In the present study, a number of new dispirobino and dispiroansa spermine derivatives of cyclotriphosphazene (8-10, 13) were synthesized and characterized by elemental analysis, mass spectrometry, H-1 and P-31 NMR spectroscopy. At first, in vitro cytotoxic activity of cyclotriphosphazene compounds (1-14) against HT-29 (human colon adenocarcinoma), Hep2 (Human epidermoid larynx carcinoma), and Vero (African green monkey kidney) cell lines was investigated. Our study showed that most of these compounds stimulate apoptosis and they have cytotoxic effects for HT-29 and Hep2 cells. Additionally, these compounds (1-14) were investigated for their antibacterial activity against gram-positive (Staphylococcus aureus), gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria and for their antifungal activity against Candida albicans, and were shown to be inactive. (C) 2012 Elsevier Masson SAS. All rights reserved. | en_US |
| dc.description.sponsorship | Scientific and Technical Research Council of Turkey TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [108T355] | en_US |
| dc.description.sponsorship | The authors thank the Scientific and Technical Research Council of Turkey for financial support TUBITAK (Grant 108T355). We are grateful to Dilek USTA for technical assistance for use of the flow cytometer at the Department of Hematology, Ondokuz Mayis University Hospital, Samsun. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier | en_US |
| dc.relation.isversionof | 10.1016/j.ejmech.2012.03.018 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Cyclotriphosphazene | en_US |
| dc.subject | Spermine derivatives | en_US |
| dc.subject | Biological activity | en_US |
| dc.subject | Cytotoxic activity | en_US |
| dc.subject | Apoptosis | en_US |
| dc.title | Synthesis, cytotoxicity and apoptosis of cyclotriphosphazene compounds as anti-cancer agents | en_US |
| dc.type | article | en_US |
| dc.contributor.department | OMÜ | en_US |
| dc.identifier.volume | 52 | en_US |
| dc.identifier.startpage | 213 | en_US |
| dc.identifier.endpage | 220 | en_US |
| dc.relation.journal | European Journal of Medicinal Chemistry | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
