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dc.contributor.authorMarangoz, Abdullah Hilmi
dc.contributor.authorYildirim, Mehmet
dc.contributor.authorAyyildiz, Mustafa
dc.contributor.authorMarangoz, Cafer
dc.date.accessioned2020-06-21T14:18:53Z
dc.date.available2020-06-21T14:18:53Z
dc.date.issued2012
dc.identifier.issn0364-3190
dc.identifier.issn1573-6903
dc.identifier.urihttps://doi.org/10.1007/s11064-012-0737-x
dc.identifier.urihttps://hdl.handle.net/20.500.12712/16478
dc.descriptionYildirim, Mehmet/0000-0003-1798-5478; AYYILDIZ, Mustafa/0000-0002-6594-3080en_US
dc.descriptionWOS: 000304878200011en_US
dc.descriptionPubMed: 22399332en_US
dc.description.abstractThe aim of this study was to investigate the interaction between nitric oxide (NO) and acetylcholine (ACh) in penicillin-induced experimental epilepsy. Adult male Wistar rats weighing 220 +/- A 35 g were used in the experiments. The epileptiform activity was induced by microinjection of penicillin (200 IU/1 mu l) into the left sensorymotor cortex. Electrocorticogram was recorded by using Ag/AgCl ball electrodes. Sodium nitroprusside (SNP), a NO donor, given intracortically 30 min after penicillin significantly reduced the spike frequency whereas ACh increased the epileptiform activity for 5 min. Atropine, an antagonist for muscarinic receptors, was given intracortically 30 min after penicillin and did not significantly affect epileptiform activity for 30 min. SNP given after atropine significantly suppressed the epileptiform activity. ACh given 10 min after N omega-nitro-l-arginine methyl ester (L-NAME), a nonspecific nitric oxide synthase inhibitor, did not have a significant effect on spike frequency. When ACh and SNP were administered together, penicillin induced epileptiform activity and spike frequency were significantly suppressed from the 10th minute onwards. It can be concluded that ACh increases the penicillin-induced epileptiform activity while co-administration of ACh and SNP produces a potent anticonvulsant effect as compared to SNP alone.en_US
dc.language.isoengen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.isversionof10.1007/s11064-012-0737-xen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylcholineen_US
dc.subjectECoGen_US
dc.subjectEpileptiform activityen_US
dc.subjectNitric oxideen_US
dc.subjectRaten_US
dc.titleThe Interactions of Nitric Oxide and Acetylcholine on Penicillin-Induced Epilepsy in Ratsen_US
dc.typearticleen_US
dc.contributor.departmentOMÜen_US
dc.identifier.volume37en_US
dc.identifier.issue7en_US
dc.identifier.startpage1465en_US
dc.identifier.endpage1474en_US
dc.relation.journalNeurochemical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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