Synthesis, characterization, and antimicrobial activity of copper(II) complexes with N,N '-propanediyl-bis-benzenesulfonamide and N,N '-ethanediyl-bis-2-methylbenzenesulfonamide

Abstract

Copper(II) complexes of new aryldisulfonamides (L (1) = N,N'-bis[(2-methylphenyl)sulfonyl]ethylenediamine) and L (2) = N,N'-propanediyl-bis-benzenesulfonamide with 1,10-phenanthroline have been synthesized and characterized by using elemental analyses, FT-IR, LCMS, conductivity, and magnetic susceptibility techniques. The structures of [Cu(phen)(2)]L-1 (1) and [CuL2(phen)(2)] (2) compounds have been determined. Complex (1) has also been characterized by single crystal X-ray diffraction. The complex (1) crystallizes in the triclinic system, space group P1, with cell constants a = 12.9353(8) , b = 13.8543(9) , c = 14.4513(10) , alpha = 103.593(5)A degrees, beta A = 113.713(5)A degrees, gamma A = 106.104(5)A degrees, and Z = 1. The antibacterial activities of synthesized compounds were studied against Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, and B. cereus and Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, and Yersinia enterocolitica by microdilution (as MICs in mu g/mL) and disk diffusion (as diameter zone in mm) method. The biological activity screening showed that (1) has more activity than (2) against the tested bacteria.