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Immunohistochemical distribution of leptin in kidney tissues of melatonin treated diabetic rats

dc.contributor.authorYildiz, S. Elis
dc.contributor.authorDeprem, T.
dc.contributor.authorSari, E. Karadag
dc.contributor.authorBingol, S. A.
dc.contributor.authorTasci, S. Koral
dc.contributor.authorAslan, S.
dc.contributor.authorSozmen, M.
dc.date.accessioned2020-06-21T13:46:51Z
dc.date.available2020-06-21T13:46:51Z
dc.date.issued2015
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.urihttps://doi.org/10.3109/10520295.2014.983548
dc.identifier.urihttps://hdl.handle.net/20.500.12712/14365
dc.descriptionWOS: 000353524300004en_US
dc.descriptionPubMed: 25539049en_US
dc.description.abstractWe examined using immunohistochemistry the distribution of leptin in kidney tissues of melatonin treated, streptozotocin (STZ) diabetic rats. The animals were divided into five groups: control, sham, melatonin-treated, diabetic and melatonin-treated diabetic. Kidney sections were prepared and stained with hematoxylin and eosin, and Crossman's triple staining for histological examination. The immunohistochemical localization of leptin in the kidney tissue was determined using the streptavidin-biotin-peroxidase method. We determined that on days 7 and 14, the leptin immunoreactivity of the diabetic and melatonin-treated diabetic groups was weaker than for the other groups. Weak immunoreactivity was found in the proximal and distal tubules of the kidney in the diabetic and melatonin-treated diabetic groups on days 7 and 14, and strong immunoreactivity was found in the control, sham and melatonin groups. Melatonin application had no significant effect on leptin production in the kidney tissues of diabetic rats.en_US
dc.description.sponsorshipKafkas University, BAPKafkas University [2012-KSYO-18]en_US
dc.description.sponsorshipOur research was supported by a grant from the Kafkas University, BAP (Project No: 2012-KSYO-18) and presented at the 21st National Electron Microscope Congress, P: 123, 28-31 May, 2013, Mersin, Turkey.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.isversionof10.3109/10520295.2014.983548en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiabetes mellitusen_US
dc.subjectimmunohistochemistryen_US
dc.subjectkidneyen_US
dc.subjectleptinen_US
dc.subjectmelatoninen_US
dc.titleImmunohistochemical distribution of leptin in kidney tissues of melatonin treated diabetic ratsen_US
dc.typearticleen_US
dc.contributor.departmentOMÜen_US
dc.identifier.volume90en_US
dc.identifier.issue4en_US
dc.identifier.startpage270en_US
dc.identifier.endpage277en_US
dc.relation.journalBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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