Which antibiotoc is better to select empirically for lower urinary tract infections in pregnant women?

Abstract

We evaluated the bacterial profiles and antibiotic sensitivities presenting in each trimester of pregnant women diagnosed with lower urinary tract infection. Escherichia coli was the most common isolated uropathogen (77.8%, 75%, and 52%, respectively), followed by Klebsiella pneumoniae (0%, 3.6%, and 16%, respectively), and Enterococcus faecalis (3.7%, 14.3%, and 8%, respectively). Ciprofloxacin was found to have sensitivity for all uropathogens, with 92.8% sensitivity for Escherichia coli and 100% for Klebsiella pneumoniae. Norfloxacin also exhibited high sensitivity for almost all bacterial agents, except Acinetobacter baumannii, with 91.4% sensitivity for Escherichia coli and 100% for Klebsiella pneumoniae. Phosphomycin had the highest sensitivity, 100%, for the two most common uropathogens, Escherichia coli and Klebsiella pneumoniae. Because empirical antimicrobial choices play a critical role in the prevention of unwanted complications, lower urinary tract infection in pregnancy can be treated with empirically selected phosphomycin.