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New copper(II) complexes including pyridine-2,5-dicarboxylic acid: synthesis, spectroscopic, thermal properties, crystal structure and how these complexes interact with purified PON 1 enzyme

Date

2016

Author

Caglar, Sema
Dilek, Esra
Alisir, Sevim Hamamci
Caglar, Bulent

Metadata

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Abstract

We report the synthesis of two square-pyramidal copper(II) complexes, [Cu(2,5-pydc)(2-aepy)(H2O)]H2O, 1, and [Cu(2,5-pydc)(2-ampy)(H2O)]H2O, 2 (2-aepy=2-(aminoethyl)pyridine, 2-ampy=2-(aminomethyl)pyridine, 2,5-pydc=pyridine-2,5-dicarboxylic acid or isocinchomeronic acid). The synthesized complexes have been characterized by X-ray diffraction, FT-IR, elemental, and thermal analysis techniques. The crystal structure of 1 was established by X-ray analysis. Powder X-ray diffraction analysis showed that the complexes are pure. The inhibition of human serum paraoxonase 1 (PON 1, EC 3.1.8.1) enzyme with these complexes were investigated. We used diethyl 4-nitrophenyl phosphate as a substrate to measure the paraoxonase activity of PON 1 enzyme spectrophotometrically. Complexes 1 and 2 decreased the in vitro PON 1 activity with different inhibition mechanisms. Complexes 1 and 2 inhibited paraoxonase activity of this enzyme as competitively and noncompetitively, respectively. [GRAPHICS] .

Source

Journal of Coordination Chemistry

Volume

69

Issue

16

URI

https://doi.org/10.1080/00958972.2016.1188295
https://hdl.handle.net/20.500.12712/13726

Collections

  • Scopus İndeksli Yayınlar Koleksiyonu [14046]
  • WoS İndeksli Yayınlar Koleksiyonu [12971]



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