dc.contributor.author | Haque, Ashanul | |
dc.contributor.author | Hsieh, Ming-Fa | |
dc.contributor.author | Hassan, Syed Imran | |
dc.contributor.author | Faizi, Md. Serajul Haque | |
dc.contributor.author | Saha, Anannya | |
dc.contributor.author | Dege, Necmi | |
dc.contributor.author | Khan, Muhammad S. | |
dc.date.accessioned | 2020-06-21T13:17:59Z | |
dc.date.available | 2020-06-21T13:17:59Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0022-2860 | |
dc.identifier.issn | 1872-8014 | |
dc.identifier.uri | https://doi.org/10.1016/j.molstruc.2017.06.027 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12712/12169 | |
dc.description | Dege, Necmi/0000-0003-0660-4721; Haque, Dr. Ashanul/0000-0002-6780-632X; Hsieh, Ming-Fa/0000-0001-5254-1341; Hasan, Syed Imran/0000-0003-1839-184X | en_US |
dc.description | WOS: 000406985800064 | en_US |
dc.description.abstract | A series of ferrocene-1H-1,2,3-triazole hybrids namely 1-(4-nitrophenyl)-4-ferrocenyl-1H-1,2,3-triazole (1), 1-(4,4'-dinitro-2-biphenyl)-4-ferrocenyl-1H-1,2,3-triazole (2), 1-(3-chloro-4-fluorophenyl)-4ferrocenyl-1H-1,2,3-triazole (3), 1-(4-bromopheny1)-4-ferroceny1-1H-1,2,3-triazole (4) and 1-(2nitrophenyl)-4-ferrocenyl-IH-1,2,3-triazole (5) were designed and synthesized by copper-catalyzed azide alkyne cycloaddition (CuAAC) reaction. All the new hybrids were characterized by microanalyses, NMR (H-1 and C-13), UV-vis, IR, ESI-MS and electrochemical techniques. Crystal structure of the compound (3) was solved by single crystal X-ray diffraction method. The structural (single crystal) and spectroscopic (UV Vis. and IR) properties of the compound 3 have been analyzed and compared by complementary quantum modeling. Hybrids 1-5 exhibited low toxicity and demonstrated neuroprotective effect. (C) 2017 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | Research Council (TRC), Oman; Ministry of Science and Technology, TaiwanMinistry of Science and Technology, Taiwan [MOST-102-2632-M-033-001-MY3] | en_US |
dc.description.sponsorship | We thank the Department of Chemistry, SQU and the Central Analytical and Applied Research Unit (CAARU) facility at Sultan Qaboos University, Oman for analytical data. AH acknowledges the Research Council (TRC), Oman for a Post-doctoral fellowship. MFH acknowledges financial support from the Ministry of Science and Technology, Taiwan under grant number MOST-102-2632-M-033-001-MY3. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.molstruc.2017.06.027 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Anti-inflammatory | en_US |
dc.subject | Click-chemistry | en_US |
dc.subject | Copper catalyzed azide alkyne cycloaddition | en_US |
dc.subject | reaction | en_US |
dc.subject | Ferrocene | en_US |
dc.subject | Viability | en_US |
dc.subject | Toxicity | en_US |
dc.title | Synthesis, characterization, and pharmacological studies of ferrocene-1H-1,2,3-triazole hybrids | en_US |
dc.type | article | en_US |
dc.contributor.department | OMÜ | en_US |
dc.identifier.volume | 1146 | en_US |
dc.identifier.startpage | 536 | en_US |
dc.identifier.endpage | 545 | en_US |
dc.relation.journal | Journal of Molecular Structure | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |