Mean Platelet Volume as a Predictive Marker for Inflammatory Reactivation after Total Hip Arthroplasty

Abstract

Objectives: Mean platelet volume (MPV) is assosiated with platelet function and activation. Increased MPV values indicate elevated platelet functions and are assosiated with inflammation. We investigated postoperative MPV changes of the patients with osteoarthritis (OA) after total hip arthroplasty. Material and Method: This retrospective study was conducted on 813 patients with coxarthrosis and 152 patients without primary coxarthrosis (control group). The patients were divided into two groups. The first group was treated with total hip arthroplasty (n=312) and the second with conservative methods (n=501). MPV, ESR, and CRP were eveluated. Early phase (up to 10 days after the operation), and late phase (>30 days postoperation) data of the patients with total hip arthroplasty were recorded. Results: Statisticaly significant differences on the mean MPV values were found between control and conservative treatment groups, and also between control and early phase surgical treatment groups (p=0.001 and p=0.005, respectively). No statistically significant difference was determined between control and late phase surgical treatment groups (p=0.796). Statisticaly significant differences were determined in the mean MPV values between conservative treatment and late phase surgical treatment groups (p=0.001), but no statistically significant difference was determined between conservative treatment and late phase surgical treatment groups (p=0.057). Conclusion: We think that changes in serum MPV values can be used as a predictive marker for inflammatory reactivation following total hip replacement surgery. The serum MPV values obtained in our study may guide future studies investigating inflammatory reactivation in hip arthroplasty surgeries.