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Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene-Bridged Cyclophosphazenes

dc.contributor.authorYildirim, Tuba
dc.contributor.authorSenkuytu, Elif
dc.contributor.authorErgene, Emel
dc.contributor.authorBilgin, Kemal
dc.contributor.authorUludag, Yildiz
dc.contributor.authorCiftci, Gonul Yenilmez
dc.date.accessioned2020-06-21T13:07:03Z
dc.date.available2020-06-21T13:07:03Z
dc.date.issued2018
dc.identifier.issn2365-6549
dc.identifier.urihttps://doi.org/10.1002/slct.201801766
dc.identifier.urihttps://hdl.handle.net/20.500.12712/11445
dc.descriptionSenkuytu, Elif/0000-0002-3579-8062en_US
dc.descriptionWOS: 000444538800024en_US
dc.description.abstractIn this study, new cyclophosphazene compounds were synthesized characterized and their biological activity studies were performed. The structural investigations of the compounds were verified by elemental analyses, mass spectrometry, H-1, P-31 NMR techniques. Later, the effects of the synthesized compounds to DNA were screened using DNA interaction analysis and cleavage methods by utilizing pUC18 plasmid. The results showed that the compounds 14, 40 and 45 caused Form III (linearized DNA) plasmid DNA, indicating the interaction of these compounds with the plasmid DNA.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [111T085]en_US
dc.description.sponsorshipThe authors thank to the Scientific and Technical Research Council of Turkey (TUBITAK) (Grant no: 111T085) for financial support. We gratefully acknowledge AUMAULAB laboratory in Amasya University (Turkey) for their contribution to the biological activity tests.en_US
dc.language.isoengen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.isversionof10.1002/slct.201801766en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiological Activityen_US
dc.subjectCyclophosphazenen_US
dc.subjectDNA Bindingen_US
dc.subjectFluorenylideneen_US
dc.subjectPhosphazeneen_US
dc.titleBiological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene-Bridged Cyclophosphazenesen_US
dc.typearticleen_US
dc.contributor.departmentOMÜen_US
dc.identifier.volume3en_US
dc.identifier.issue34en_US
dc.identifier.startpage9933en_US
dc.identifier.endpage9939en_US
dc.relation.journalChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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