Molar incisor hypomineralization in children with systemic diseases

Abstract

Introduction/Objective Molar incisor hypomineralization (MIH) is an important clinical problem, but its exact etiology is unknown. The aim of this study was to evaluate MIH in children with systemic diseases diagnosed before the age of four and assess whether systemic diseases are a risk factor for the development of MIH. Methods A total of 394 children aged eight and older, who had been diagnosed with a systemic disease under the age of four were included in the study group. A total of 18 different systemic diseases were assessed. An additional 394 children with no systemic disease were included in the control group. All the children were evaluated for the presence of MIH. Results The frequency of MIH in the study group and control group was found to be 28.93% and 23.60%, respectively (p < 0.05). Of all the systemic diseases evaluated in this study [nephrotic syndrome (OR = 1), congenital hypothyroid (OR =0.96; 95% CI: 0.22-4.10), and Wilms' tumor (OR = 0.57; 95% CI: 0.07-4.64)] were determined to be risk factors for the development of MIH. Conclusion Wilms' tumor, congenital hypothyroid, and nephrotic syndrome may be considered to be risk factors for MIH.