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dc.contributor.authorKoc, Ozgur M.
dc.contributor.authorRobaeys, Geert
dc.contributor.authorYildirim, Beytullah
dc.contributor.authorPosthouwer, Dirk
dc.contributor.authorHens, Niel
dc.contributor.authorKoek, Ger H.
dc.date.accessioned2020-06-21T12:27:24Z
dc.date.available2020-06-21T12:27:24Z
dc.date.issued2019
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.urihttps://doi.org/10.1002/jmv.25353
dc.identifier.urihttps://hdl.handle.net/20.500.12712/10920
dc.descriptionWOS: 000458577200014en_US
dc.descriptionPubMed: 30381836en_US
dc.description.abstractSince the cultural diversity in Western Europe is growing, this study assessed whether foreign-born chronic hepatitis B (CHB) patients have more cirrhosis than Dutch- or Belgian-born patients, with a main focus on the Turkish population. Baseline characteristics (eg, socioeconomic status [SES]), biological characteristics, and disease outcome (eg, cirrhosis) were collected for all patients. Between December 2009 and January 2015, 269 CHB patients participated from the outpatient departments of three hospitals in the Netherlands, Belgium, and Turkey. Out of the 269 CHB patients, 210 were foreign-born and 59 were Dutch- or Belgian-born. Compared with Dutch- or Belgian-born patients, foreign-born patients had a higher prevalence of low SES (58% vs 31%; P = 0.001) and cirrhosis (27% vs 10%; P = 0.007). Among the Turkish population, there were no significant differences regarding the prevalence of low SES (73% vs 61%; P = 0.170), alcohol abuse (1% vs 5%; P = 0.120), anti-hepatitis C virus positivity (4% vs 0%; P = 0.344), anti-hepatitis D virus positivity (1% vs 6%; P = 0.297), and cirrhosis (37% vs 27%; P = 0.262) between patients (n = 102) living in Turkey (local) and Turkish CHB (n = 38) patients living in the Netherlands or Belgium (immigrant). In multivariate analysis, low SES (odds ratio, 5.7; 95% confidence interval, 2.3-14.5; P < 0.001) was associated with cirrhosis. In this study, foreign-born CHB patients were associated with more advanced HBV-related liver disease with 27% having cirrhosis. However, ethnicity was not associated with cirrhosis when SES was included in the multivariate analysis. The similar prevalence of cirrhosis in local Turkish compared to immigrant Turkish CHB patients is novel and warrants further investigation.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/jmv.25353en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcirrhosisen_US
dc.subjectdisease outcomeen_US
dc.subjectethnicityen_US
dc.subjecthepatitis Ben_US
dc.subjectsocioeconomic statusen_US
dc.subjectTurkishen_US
dc.titleThe influence of ethnicity on disease outcome in patients with chronic hepatitis B infectionen_US
dc.typearticleen_US
dc.contributor.departmentOMÜen_US
dc.identifier.volume91en_US
dc.identifier.issue4en_US
dc.identifier.startpage623en_US
dc.identifier.endpage629en_US
dc.relation.journalJournal of Medical Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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