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dc.contributor.authorCirak, Cuneyt
dc.contributor.authorRadusiene, Jolita
dc.date.accessioned2020-06-21T12:25:56Z
dc.date.available2020-06-21T12:25:56Z
dc.date.issued2019
dc.identifier.issn2676-8615
dc.identifier.issn2676-8607
dc.identifier.urihttps://doi.org/10.1556/019.70.2019.25
dc.identifier.urihttps://hdl.handle.net/20.500.12712/10602
dc.descriptionWOS: 000509671500004en_US
dc.description.abstractThe genus Hypericum (Hypericaceae) consists of 484 species from 36 sections with worldwide distribution in different areas. Turkey is considered as hot spot for diversity of Hypericum genus. Despite numerous publications, Hypericum species still attracted considerable scientific interest due to pharmaceutically relevant secondary metabolites: naphthodianthrones, acylphloroglucinol derivatives, phenolic acids, flavonoid glycosides, biflavonoids, and some other valuable constituents. Phytochemical investigations carried out on different Hypericum species provided highly heterogeneous results. The content of bioactive compounds varies significantly due to many internal and external factors, including plant organs, phenological stage, genetic profile, environmental abiotic and biotic factors, such as growing site, light, temperature, radiation, soil drought and salinity, pathogens, and herbivores attack. The variations in content of bioactive compounds in plants are regarded as the main problem in the standardization of Hypericum-derived pharmaceuticals and dietary supplements. The review discusses the main factors contributing to the variations of bioactive compounds and what kind of modulations can increase quality of Hypericum raw material.en_US
dc.language.isoengen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.isversionof10.1556/019.70.2019.25en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectabiotic and biotic factorsen_US
dc.subjectvariation of bioactive compoundsen_US
dc.subjecthyperforinen_US
dc.subjecthypericinen_US
dc.subjectHypericum speciesen_US
dc.titleFactors affecting the variation of bioactive compounds in Hypericum speciesen_US
dc.typearticleen_US
dc.contributor.departmentOMÜen_US
dc.identifier.volume70en_US
dc.identifier.issue3en_US
dc.identifier.startpage198en_US
dc.identifier.endpage209en_US
dc.relation.journalBiologia Futuraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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