Spectroscopic, structural characterization and magnetic studies of Cu(II)-sulfathiazole complex with 1,10-Phenanthroline and N-(2-hydroxyethyl)-Ethylenediamine ligands

Abstract

Cu(II)-sulfathiazole (Hstz:4-amino-N-(1,3-thiazol-2-yl) benzene sulfonamide) complex with phen (1,10-Phenanthroline) and Hydeten (N-(2-hydroxyethyl)-Ethylenediamine) has been synthesized and characterized by single crystal X-ray diffraction, IR, EPR and UV-Vis spectroscopy, thermal analysis. The [Cu(stz)(Hydeten)(Phen)].(stz)(Phen) complex crystallizes in the orthorhombic space group Pca2(1), Z = 4. The sulfathiazole anion acts as a monodentate ligand through the thiadiazole N atom contiguous to the deprotonated sulfonamide group. The trigonality factor (tau = (beta-alpha)/60) value of the copper complex is 0.14 and this value expresses having slightly distorted square pyramidal environment of the Cu(II) ions coordination. The powder EPR spectra of Cu(II) complex were recorded at room temperature and liquid nitrogen temperature. The EPR spectral analysis has led to that the ground state of the unpaired electron of copper ion isd(x2-y2). As results of the minimum inhibitory concentration (MIC) values obtained as results of the antimicrobial study for stz and complex, it was seen that the metal-stz complex was more effective than free stz. (C) 2019 Elsevier B.V. All rights reserved.