Browsing by Author "Okuyucu, Ali"
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The anticancer effects of desferrioxamine on human breast adenocarcinoma and hepatocellular carcinoma cells
Salis, Osman; Bedir, Abdulkerim; Kilinc, Veli; Alacam, Hasan; Gulten, Sedat; Okuyucu, Ali (Ios Press, 2014)N-myc downstream-regulated gene 1 (NDRG1) is defined as metastasis suppressor and can be downregulated in many types of cancers, and reported to be an indication of tumor progression in hepatocellular carcinomas. Several ... -
Antimetastatic effect of fluvastatin on breast and hepatocellular carcinoma cells in relation to SGK1 and NDRG1 genes
Salis, Osman; Okuyucu, Ali; Bedir, Abdulkerim; Gor, Ufuk; Kulcu, Canan; Yenen, Eser; Kilic, Nermin (Sage Publications Ltd, 2016)Metastasis occurs due to migration of the cells from primary tumor toward other tissues by gaining invasive properties. Since metastatic invasion shows a strong resistance against conventional cancer treatments, the studies ... -
Cytotoxic Effect of Fluvastatin on MCF-7 Cells Possibly Through a Reduction of the mRNA Expression Levels of SGK1 and CAV1
Salis, Osman; Bedir, Abdulkerim; Gulten, Sedat; Okuyucu, Ali; Kulcu, Canan; Alacam, Hasan (Mary Ann Liebert, Inc, 2014)Fluvastatin (FLU) prevents the conversion of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonic acid by inhibiting HMG-CoA reductase and decreases cholesterol level. Although the effects of FLU treatment on several ... -
Do iron chelators increase the antiproliferative effect of trichostatin A through a glucose-regulated protein 78 mediated mechanism?
Kilinc, Veli; Bedir, Abdulkerim; Okuyucu, Ali; Salis, Osman; Alacam, Hasan; Gulten, Sedat (Sage Publications Ltd, 2014)Histone deacetylase (HDAC) inhibitors, such as trichostatin A (TSA), and iron chelators, including deferoxamine (DFO) and phenanthroline (PHEN), appear to have anticancer effects. We hypothesized that the HDAC inhibitors ... -
Does ADMA affect the oxidant/antioxidant balance in rats?
Alacam, Hasan; Avci, Bahattin; Salis, Osman; Dilek, Ahmet; Kozan, Ahmet; Mertoglu, Cuma; Okuyucu, Ali (Tubitak Scientific & Technical Research Council Turkey, 2013)Aim: Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide synthase (NOS). Oxidative stress might be defined as an imbalance between protein oxidation and antioxidants. Our aim was to determine in vivo whether ... -
Effect of free creatine therapy on cisplatin-induced renal damage
Genc, Gurkan; Okuyucu, Ali; Meydan, Bilge Can; Yavuz, Oguzhan; Nisbet, Ozlem; Hokelek, Murat; Ozkaya, Ozan (Informa Healthcare, 2014)Cisplatin is one of the commonly used anticancer drugs and nephrotoxicity limits its use. The aim of this study is to investigate the possible protective effect of creatine supplementation on cisplatin-induced nephrotoxicity. ... -
The Effectiveness of the Serum Surfactant Protein D (Sp-D) Level to Indicate Lung Injury in Pulmonary Embolism
Kati, Celal; Alacam, Hasan; Duran, Latif; Guzel, Aygul; Akdemir, Hizir Ufuk; Sisman, Bulent; Okuyucu, Ali (Clin Lab Publ, 2014)Background: Surfactant protein D (SP-D) is a biomarker specific to the lungs. Our aim was to investigate the relationship between clinical probability scores and the serum levels of SP-D to indicate the severity of lung ... -
The evaluation of central corneal thickness and intraocular pressure in conjunction with tear IGF-1 levels in patients with acromegaly
Kan, Emrah; Kan, Elif K.; Okuyucu, Ali (Wichtig Publishing, 2017)Purpose: To compare the central corneal thickness (CCT), intraocular pressure (IOP), and tear insulin-like growth factor 1 (IGF-1) levels between patients with acromegaly and a control group and to evaluate the possible ... -
The Evaluation of Serum Surfactant Protein D (SP-D) Levels as a Biomarker of Lung Injury in Tuberculosis and Different Lung Diseases
Guzel, Aygul; Karadag, Adil; Okuyucu, Ali; Alacam, Hasan; Kucuk, Yasemin (Clin Lab Publ, 2014)Background: To evaluate the predictive powers of serum surfactant protein D (SP-D) levels as a biomarker of lung damage in tuberculosis and lung diseases. Methods: This study prospectively included 137 subjects who applied ... -
Helicobacter Pylori Eradication Increases Telomere Length in Gastric Mucosa
Aslan, Rahmi; Bektas, Ahmet; Bedir, Abdulkerim; Alacam, Hasan; Aslan, Melek Suzer; Nar, Rukiye; Okuyucu, Ali (H G E Update Medical Publishing S A, 2013)Background/Aims: Our purpose in this study was to analyze telomere length and telomerase activity before and after eradication treatment in gastric mucosa in patients positive for H. pylori. Methodology: There were two ... -
Investigation of Genotoxicity in Intestinal Epithelial Cells and Lymphocytes of Celiac Patients
Yuce, Ozlem; Kalayci, Ayhan Gazi; Okuyucu, Ali; Caltepe, Gonul; Bedir, Abdulkerim (Nobel Ilac, 2015)Objective: To investigate the presence of genotoxicity in intestinal epithelial cells and lymphocytes in celiac patients and to assess DNA repair capacity. Material and Method: The study comprised 15 newly diagnosed celiac ... -
Is there any role of epithelial to mesenchymal transition in the pathogenesis of contrast nephropathy?
Sayarlioglu, Hayriye; Okuyucu, Ali; Bedir, Abdulkerim; Salis, Osman; Yenen, Eser; Bekfilavioglu, Garip; Kaya, Coskun (Taylor & Francis Ltd, 2016)Aim: Contrast medium-induced nephropathy is one of the major complications of intravenous contrast medium use. But its pathogenesis is unclear. Epithelial mesenchymal transition (EMT) is defined as the transformation of ... -
Is Vitamin D Deficiency a Risk Factor for Respiratory Distress Syndrome?
Ataseven, Fevzi; Aygun, Canan; Okuyucu, Ali; Bedir, Abdulkerim; Kucuk, Yasemin; Kucukoduk, Sukru (Verlag Hans Huber, 2013)Background: Previous studies have shown the relationship between in utero lung development and vitamin D [25(OH)D], but there have been no studies to investigate whether vitamin D deficiency is a risk factor for respiratory ... -
The Neuroprotective Effect of Glycyrrhizic Acid on an Experimental Model of Focal Cerebral Ischemia in Rats
Akman, Tarik; Guven, Mustafa; Aras, Adem Bozkurt; Ozkan, Adile; Sen, Halil Murat; Okuyucu, Ali; Cosar, Murat (Springer/Plenum Publishers, 2015)Cerebral ischemia is still one of the most important topics in neurosciences. Our study aimed to investigate the neuroprotective and anti-oxidant effects of glycyrrhizic acid on focal cerebral ischemia in rats. Twenty-four ... -
The Protective Effect of Ascorbic Acid on Exogenous Asymmetric Dimethylarginine Induced Intimal Thickness and Cholesterol Increase in Rats
Okuyucu, Ali; Salis, Osman; Alici, Omer; Ilkaya, Fatih; Altuntas, Aynur; Guvenli, Abdullah; Alacam, Hasan (Carbone Editore, 2015)Introduction: The endothelium plays an important role in maintaining vascular structure and waits; and endothelial cells are protective against the thrombosis and atherosclerosis. Cardiovascular risk factors, such as ... -
The Relationship Between Coronary Slow Flow and Urotensin II
Zengin, Halit; Erbay, Ali Riza; Alacam, Hasan; Okuyucu, Ali; Yuksel, Serkan; Meric, Murat; Sahin, Mahmut (Elsevier Science Inc, 2013)… -
The relationship between coronary slow flow phenomenon and urotensin-II: A prospective and controlled study
Zengin, Halit; Erbay, Ali Riza; Okuyucu, Ali; Alacam, Hasan; Yuksel, Serkan; Meric, Murat; Sahin, Mahmut (Turkish Soc Cardiology, 2015)Objective: The underlying mechanism of coronary slow flow (CSF) has not yet been clarified, although many studies have been conducted to understand its pathophysiology. In this study, we investigated the role of a very ... -
Reliability of Pro-adrenomedullin and Interleukin 1 beta in Predicting Severity of Community-Acquired Pneumonia in Pediatric Patients
Korkmaz, Muhammet Furkan; Guzel, Ahmet; Acikgoz, Mehmet; Okuyucu, Ali; Alacam, Hasan (Assoc Clinical Scientists, 2018)Objectives. Community-acquired pneumonia (CAP) in children is one of the most important causes of mortality and morbidity in developing countries. Therefore, it is very important for clinicians to detect the presence and ...
