Browsing by Author "Balaydin, Halis Turker"
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Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds
Balaydin, Halis Turker; Durdagi, Serdar; Ekinci, Deniz; Senturk, Murat; Goksu, Suleyman; Menzek, Abdullah (Taylor & Francis Ltd, 2012)Carbonic anhydrase inhibitors (CAI) are valuable molecules as they have several therapeutic applications, including anti-glaucoma activity. In this study, inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) ... -
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site
Durdagi, Serdar; Senturk, Murat; Ekinci, Deniz; Balaydin, Halis Turker; Goksu, Suleyman; Kufrevioglu, O. Irfan; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2011)Carbonic anhydrases (CAs, EC 4.2.1.1) are inhibited by sulfonamides, inorganic anions, phenols, coumarins (acting as prodrugs) and polyamines. A novel class of CA inhibitors (CAIs), interacting with the CA isozymes I, II ... -
Synthesis and Biological Evaluation of Novel Bromophenol Derivatives as Carbonic Anhydrase Inhibitors
Akbaba, Yusuf; Balaydin, Halis Turker; Menzek, Abdullah; Goksu, Suleyman; Sahin, Ertan; Ekinci, Deniz (Wiley-V C H Verlag Gmbh, 2013)Here, we provide an alternative synthesis of the natural bromophenol 3,4-dibromo-5-(2,3-dibromo-4,5-dihydroxybenzyl)-6-(ethoxymethyl) benzene-1,2-diol (3) and the first synthesis of (4,5-dihydroxy-2methylphenyl)( ... -
Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural products
Balaydin, Halis Turker; Soyut, Hakan; Ekinci, Deniz; Goksu, Suleyman; Beydemir, Sukru; Menzek, Abdullah; Sahin, Ertan (Taylor & Francis Ltd, 2012)(2-Bromo-3,4-dimethoxyphenyl) (3,4-dimethoxyphenyl) methanone (10) and its derivatives with Br, one dibromide and isomeric three tribromides, were synthesized. Demethylation of these compounds afforded a series of new ...
