Yazar "Yildirim, Mehmet" için listeleme
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Anticonvulsant effects of focal and intracerebroventricular adenosine on penicillin-induced epileptiform activity in rats
Yildirim, Mehmet; Marangoz, Cafer (Elsevier Science Bv, 2007)Adenosine has potent anticonvulsant effects on various models of experimental epilepsy. In the present study, we examined the effects of focal and intracerebroventricular (i.c.v.) adenosine on penicillin-induced epileptiform ... -
Anticonvulsant effects of melatonin on penicillin-induced epileptiform activity in rats
Yildirim, Mehmet; Marangoz, Cafer (Elsevier Science Bv, 2006)In the present study, we investigated the effects of melatonin on penicillin-induced epileptiform activity in female Wistar rats. The left cereoral cortex was exposed by craniotomy under urethane anesthesia for the induction ... -
The effect of alpha-tocopherol in the acute ethanol intake and its withdrawal on penicillin-induced epilepsy
Kozan, Ramazan; Ayyildiz, Mustafa; Yildirim, Mehmet; Agar, Erdal (Nencki Inst Experimental Biology, 2009)The present study was designed to investigate the influence of acute ethanol intake and its withdrawal on the anticonvulsant effect of alpha-tocopherol in penicillin-induced epileptiform activity. Ethanol-treated rats ... -
The effect of co-administration of the NMDA blocker with agonist and antagonist of CB1-receptor on penicillin-induced epileptiform activity in rats
Cakil, Duygu; Yildirim, Mehmet; Ayyildiz, Mustafa; Agar, Erdal (Elsevier Science Bv, 2011)Although the activation of CB1-receptor by cannabinoids and block of NMDA receptors are known to decrease seizure severity in epilepsy models, the interaction between these systems remain elusive. Therefore, the present ... -
The effect of combined treatment of alpha-tocopherol, ascorbic acid, and pyridoxine with NMDA blocker memantine on penicillin-induced epileptiform activity in rats
Aydin, Duygu; Yildirim, Mehmet; Ayyildiz, Mustafa; Agar, Erdal (Tubitak Scientific & Technical Research Council Turkey, 2013)Aim: To evaluate the effects of coadministration of vitamins alpha-tocopherol, ascorbic acid, and pyridoxine with memantine on a penicillin-induced experimental epilepsy model in rats so as to clarify the eventual interaction ... -
The effects of ascorbic acid on penicillin-induced epileptiform activity in rats
Ayyildiz, Mustafa; Coskun, Sule; Yildirim, Mehmet; Agar, Erdal (Wiley, 2007)Purpose: Epileptic seizure results from excessive discharge in a population of hyperexcitable neurons. A number of studies help to document the effects of active oxygen free radical scavengers such as alpha-tocopherol or ... -
The effects of ethanol intake and withdrawal on penicillin-induced epileptiform activity in rats
Kozan, Ramazan; Ayyildiz, Mustafa; Yildirim, Mehmet; Agar, Erdal (Pergamon-Elsevier Science Ltd, 2006)Previous experiments have shown that ethanol may have either pro-convulsive or anti-convulsive effects on epileptic activity in different experimental epilepsy models. In this study, the effect of low dose ethanol and its ... -
The effects of hemostatic agents on peripheral nerve function: An experimental study
Alkan, Alper; Inal, Samet; Yildirim, Mehmet; Bas, Burcu; Agar, Erdal (W B Saunders Co-Elsevier Inc, 2007)Purpose: in the practice of oral and maxillofacial surgery, hemostatic agents are sometimes placed in close proximity to peripheral nerves. In the present study, we evaluated immediate and delayed effects of 4 hemostatic ... -
The effects of vitamin E on penicillin-induced epileptiform activity in rats
Ayyildiz, Mustafa; Yildirim, Mehmet; Agar, Erdal (Springer, 2006)Epilepsy is a disorder characterized by recurrent seizures, which can increase the content of reactive oxygen in the brain. Active oxygen free radical scavengers such as ascorbic acid or alpha-tocopherol (vitamin E) might ... -
Endothelial nitric oxide synthase activity involves in the protective effect of ascorbic acid against penicillin-induced epileptiform activity
Yildirim, Mehmet; Ayyildiz, Mustafa; Agar, Erdal (W B Saunders Co Ltd, 2010)Ascorbic acid and nitric oxide are known to play important roles in epilepsy. The aim of present study was to identify the involvement of nitric oxide (NO) in the anticonvulsant effects of ascorbic acid on penicillin-induced ... -
The influence of ethanol intake and its withdrawal on the anticonvulsant effect of alpha-tocopherol in the penicillin-induced epileptiform activity in rats
Kozan, Ramazan; Ayyildiz, Mustafa; Yildirim, Mehmet; Agar, Erdal (Elsevier, 2007)Previous studies proposed the existence of a relationship between epilepsy and ethanol. Ethanol may have either proconvulsive or anticonvulsive effects on epileptic activity in different experimental epilepsy models. The ... -
Interaction of leptin and nitric oxide pathway on penicillin-induced epileptiform activity in rats
Aslan, Ali; Yildirim, Mehmet; Ayyildiz, Mustafa; Guven, Ayla; Agar, Erdal (Elsevier Science Bv, 2010)The aim of the present study was to investigate the role of NO as a mediator of leptin action at the penicillin-induced epileptiform activity in rat. Thirty minutes after penicillin injection, leptin, at a dose of 1 rig, ... -
The Interactions of Nitric Oxide and Acetylcholine on Penicillin-Induced Epilepsy in Rats
Marangoz, Abdullah Hilmi; Yildirim, Mehmet; Ayyildiz, Mustafa; Marangoz, Cafer (Springer/Plenum Publishers, 2012)The aim of this study was to investigate the interaction between nitric oxide (NO) and acetylcholine (ACh) in penicillin-induced experimental epilepsy. Adult male Wistar rats weighing 220 +/- A 35 g were used in the ... -
The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats
Yildirim, Mehmet; Marangoz, Abdullah H.; Ayyildiz, Mustafa; Ankarali, Seyit; Marangoz, Cafer (Nencki Inst Experimental Biology, 2011)In this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examined in rats. NO donor, sodium nitroprusside (SNP, 50 mu g/rat, i.c.v.) reduced the frequency but ... -
The involvement of nitric oxide in the anticonvulsant effects of alpha-tocopherol on penicillin-induced epileptiform activity in rats
Ayyildiz, Mustafa; Yildirim, Mehmet; Agar, Erdal (Elsevier Science Bv, 2007)A variety of animal seizure models exist which help to document the effects of alpha-tocopherol (Vitamin E) and specify its action. In the present study, we provide further evidence for the functional involvement of NO in ... -
The role of nitric oxide in the anticonvulsant effects of pyridoxine on penicillin-induced epileptiform activity in rats
Bosnak, Mehmet; Ayyildiz, Mustafa; Yildirim, Mehmet; Agar, Erdal (Elsevier Science Bv, 2007)The present study was conducted to identify the role of nitric oxide (NO) in the anticonvulsant effects of pyridoxine hydrochloride on penicillin-induced epileptiform activity in rats. A single microinjection of penicillin ... -
The role of nitric oxide in the inhibitory effect of ghrelin against penicillin-induced epileptiform activity in rat
Aslan, Ali; Yildirim, Mehmet; Ayyildiz, Mustafa; Guven, Ayla; Agar, Erdal (Churchill Livingstone, 2009)Ghrelin, a gastric peptide with key action on food intake, has been recently recognized as a potential anti-epileptic agent. In the present study, we investigated the involvement of nitric oxide in the effect of ghrelin ...
