Yazar "Yang, Xiuli" için listeleme
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Analysis of Borrelia burgdorferi Proteome and Protein-Protein Interactions
Yang, Xiuli; Thakur, Meghna; Koci, Juraj; Smith, Alexis A.; Singh, Preeti; Zhuang, Xuran; Pal, Utpal (Humana Press Inc, 2018)The proteome of Borrelia burgdorferi undergoes dynamic alterations as the microbe cycles through and persists in diverse host or vector environments. Therefore, studies of B. burgdorferi proteome and protein-protein ... -
A Borrelia burgdorferi Surface-Exposed Transmembrane Protein Lacking Detectable Immune Responses Supports Pathogen Persistence and Constitutes a Vaccine Target
Kung, Faith; Kaur, Simarjot; Smith, Alexis A.; Yang, Xiuli; Wilder, Cara N.; Sharma, Kavita; Pal, Utpal (Oxford Univ Press Inc, 2016)Borrelia burgdorferi harbors a limited set of transmembrane surface proteins, most of which constitute key targets of humoral immune responses. Here we show that BB0405, a conserved membrane-spanning protein of unknown ... -
Cross-Species Interferon Signaling Boosts Microbicidal Activity within the Tick Vector
Smith, Alexis A.; Navasa, Nicolas; Yang, Xiuli; Wilder, Cara N.; Buyuktanir, Ozlem; Marques, Adriana; Pal, Utpal (Cell Press, 2016)Evolution of hematophagy in blood-sucking parasites likely involves communication with their hosts. We find that Ixodes ticks are responsive to IFNg acquired in a blood meal from mice infected with the Lyme disease-causing ... -
Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection
Yang, Xiuli; Lin, Yi-Pin; Heselpoth, Ryan D.; Buyuktanir, Ozlem; Qin, Jinhong; Kung, Faith; Pal, Utpal (Wiley, 2016)Borrelia burgdorferi surface-located membrane protein 1, also known as Lmp1, has been shown to play critical roles in pathogen evasion of host-acquired immune defences, thereby facilitating persistent infection. Lmp1 ...
