Yazar "Tekcan, Akin" için listeleme
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Association between fibromyalgia syndrome and polymorphism of the IL-4 gene in a Turkish population
Yigit, Serbulent; Inanir, Ahmet; Tekcan, Akin; Inanir, Sema; Tural, Sengul; Ates, Omer (Elsevier Science Bv, 2013)Purpose: Fibromyalgia (FM) syndrome is a form of non-articular rheumatism characterized by long term and widespread musculoskeletal pain, morning stiffness, sleep disturbance, paresthesia, and pressure hyperalgesia at ... -
C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma
Tekcan, Akin; Gumusay, Ozge; Nursal, Ayse Feyda; Yigit, Serbulent; Yildiz, Serkan; Tumer, Mehmet Kemal (Kare Publ, 2020)OBJECTIVE Oral squamous cell carcinoma (OSCC) is the most frequently seen oral malignancy and accounts for up to 80-90% of all malignant neoplasms that occurin the oral cavity. The p53 tumor suppressor gene plays a crucial ... -
A Case with Partial 9p Trisomy and Speech Impairment
Elbistan, Mehrnet; Tekcan, Akin; Tural, Sengul; Karakus, Nevin; Kara, Nurten (Derman Medical Publ, 2015)In this study, we aimed to discuss the relationships between his phenotypic anomalies and der(15), ish t(9; 15)(p12; q10) balanced reciprocal translocation entity that determined from 5 year old male child who referred to ... -
The combined QF-PCR and cytogenetic approach in prenatal diagnosis
Tekcan, Akin; Tural, Sengul; Elbistan, Mehmet; Kara, Nurten; Guven, Davut; Kocak, Idris (Springer, 2014)In this study, the importance of quantitative fluorescence polymerase chain reaction (QF-PCR) aneuploidy diagnosis test which provides earlier and easier results were discussed. The cell cultures and DNA isolations were ... -
Effects of subtelomeric copy number variations in miscarriages
Tekcan, Akin; Elbistan, Mehmet; Tural, Sengul; Cetinkaya, Mehmet Bilge (Taylor & Francis Ltd, 2015)Purpose: This study was performed on miscarriage samples for chromosome analysis to detect copy number variations (CNVs) related to subtelomeric regions, and with these results we aimed to adapt multiplex ligation-dependent ... -
Evaluation of apoptotic cell death on liver and kidney tissues following administration of levetiracetam during prenatal period
Tekcan, Akin; Tural, Sengul; Elbistan, Mehmet; Guvenc, Tolga; Ayas, Bulent; Kara, Nurten (Taylor & Francis Ltd, 2017)Objective: Levetiracetam is a new generation antiepileptic drug used in treatment of patients with epilepsy and has adverse effects on different tissues. We aimed to evaluate the apoptotic effects of levetiracetam exposure ... -
FMR1 gene mutation screening by TP-PCR in patients with premature ovarian failure and fragile-X
Tural, Sengul; Tekcan, Akin; Kara, Nurten; Elbistan, Mehmet; Guven, Davut; Tasdemir, Haydar Ali (Informa Healthcare, 2015)CGG repeat expansion in the FMR1 gene is associated with fragile X syndrome, fragile X-associated tremor/ ataxia syndrome and fragile X-associated primary ovarian insufficiency. In this study, FMR1 gene mutation screening ... -
Genotoxic Effects of Prenatal Exposure to Levetiracetam During Pregnancy on Rat Offsprings
Tural, Sengul; Tekcan, Akin; Elbistan, Mehmet; Karakus, Nevin; Ozyurek, Hamit; Kara, Nurten (Int Inst Anticancer Research, 2015)Levetiracetam is a new-generation antiepileptic drug initially approved as an adjunctive treatment for patients with refractory partial seizures and is now also used as a monotherapy. The aim of this study was to evaluate ... -
IL-4 and MTHFR gene polymorphism in rheumatoid arthritis and their effects
Inanir, Ahmet; Yigit, Serbulent; Tekcan, Akin; Tural, Sengul; Kismali, Gorkem (Elsevier, 2013)Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that mainly affects the joints. Polymorphic variations of the cytokine genes and MTHFR gene have received attention as potential markers of susceptibility, ... -
Investigation of Associations between Obesity and LEP G2548A and LEPR 668A/G Polymorphisms in a Turkish Population
Sahin, Server; Rustemoglu, Aydin; Tekcan, Akin; Tasliyurt, Turker; Guven, Hasan; Yigit, Serbulent (Hindawi Publishing Corporation, 2013)Objective. Obesity is a complex heterogeneous disease that is caused by genes, environmental factors, and the interaction between the two. The leptin (LEP) and leptin receptor (LEPR) genes have been evaluated for polymorphisms ... -
The Investigation of Obesity Susceptibility with IL-4 Gene Intron 3 VNTR and IL-6 Gene-597G/A Polymorphisms in a Turkish Population
Tekcan, Akin; Yigit, Serbulent; Rustemoglu, Aydin; Gurel, Cevik; Sahin, Server; Tasliyurt, Turker (Kamla-Raj Enterprises, 2013)Obesity results in a proinflammatory state starting within the metabolic cells as adipocyte, monocyte. The bioactive system, including cytokines as IL-4 and IL-6, contributes to the pathogenesis of conditions associated ... -
Macrophage Migration Inhibitory Factor-173GC Variant Might Increase the Risk of Behcet's Disease
Nursal, Ayse Feyda; Yigit, Serbulent; Tural, Ercan; Kalkan, Goknur; Tumer, Mehmet Kemal; Tekcan, Akin (Karger, 2018)Objective: The aim of the present study was to investigate any possible association between the macrophage migration inhibitory factor (MIF) -173GC variant and Behcet's disease (BD) in a group of Turkish patients. Subjects ... -
Molecular Analysis of Genetic Variation in Angiotensin I-Converting Enzyme Gene in Turkish Athletes
Inanir, Ahmet; Cenikli, Abdullah; Tural, Ercan; Tekcan, Akin; Tural, Sengul; Cakil, Duygu; Yigit, Serbulent (Kamla-Raj Enterprises, 2014)Genetic factors play an important role in physical performance. The angiotensin converting enzyme (ACE) gene polymorphism is the most studied genetic marker in the field of human performance. The aim of this study was to ... -
The role of IL-4 gene 70 bp VNTR and ACE gene I/D variants in Familial Mediterranean fever
Yigit, Serbulent; Tural, Sengul; Tekcan, Akin; Tasliyurt, Turker; Inanir, Ahmet; Uzunkaya, Suheyla; Kismali, Gorkem (Academic Press Ltd- Elsevier Science Ltd, 2014)Familial Mediterranean fever (FMF) is characterized by recurrent attacks of fever and inflammation in the peritoneum, synovium, or pleura, accompanied by pain. It is an autosomal recessive disease caused by mutations in ... -
Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis
Yigit, Serbulent; Inanir, Ahmet; Tekcan, Akin; Tural, Ercan; Ozturk, Gokhan Tuna; Kismali, Gorkem; Karakus, Nevin (Elsevier, 2014)Objective: Interleukin-4 (IL-4) is a strong chondroprotective cytokine and polymorphisms within this gene may be a risk factor for osteoarthritis (OA). We aimed to investigate genotype and allele frequencies of IL-4 gene ... -
Sister chromatid exchanges in breast cancer patients who underwent chemotherapy
Tekcan, Akin; Elbistan, Mehmet; Ulusoy, Ali Naki (Japanese Soc Toxicological Sciences, 2012)The study aimed to determine the effects of cytostatic and genotoxic drugs used to treat breast cancer on sister chromatid exchange (SCE). SCE values were examined in 25 female patients with breast cancer in pre-treatment, ...
