Yazar "Smith, Alexis A." için listeleme
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Analysis of Borrelia burgdorferi Proteome and Protein-Protein Interactions
Yang, Xiuli; Thakur, Meghna; Koci, Juraj; Smith, Alexis A.; Singh, Preeti; Zhuang, Xuran; Pal, Utpal (Humana Press Inc, 2018)The proteome of Borrelia burgdorferi undergoes dynamic alterations as the microbe cycles through and persists in diverse host or vector environments. Therefore, studies of B. burgdorferi proteome and protein-protein ... -
Borrelia burgdorferi BBI39 Paralogs, Targets of Protective Immunity, Reduce Pathogen Persistence Either in Hosts or in the Vector
Singh, Preeti; Verma, Deepshikha; Backstedt, Brian T.; Kaur, Simarjot; Kumar, Manish; Smith, Alexis A.; Pal, Utpal (Oxford Univ Press Inc, 2017)Borrelia burgdorferi genome harbors several paralogous gene families (pgf) that can encode immunogenic proteins of unknown function. Protein-protein interaction assays using a transmission-blocking vaccine candidate, BBA52, ... -
A Borrelia burgdorferi Surface-Exposed Transmembrane Protein Lacking Detectable Immune Responses Supports Pathogen Persistence and Constitutes a Vaccine Target
Kung, Faith; Kaur, Simarjot; Smith, Alexis A.; Yang, Xiuli; Wilder, Cara N.; Sharma, Kavita; Pal, Utpal (Oxford Univ Press Inc, 2016)Borrelia burgdorferi harbors a limited set of transmembrane surface proteins, most of which constitute key targets of humoral immune responses. Here we show that BB0405, a conserved membrane-spanning protein of unknown ... -
Cross-Species Interferon Signaling Boosts Microbicidal Activity within the Tick Vector
Smith, Alexis A.; Navasa, Nicolas; Yang, Xiuli; Wilder, Cara N.; Buyuktanir, Ozlem; Marques, Adriana; Pal, Utpal (Cell Press, 2016)Evolution of hematophagy in blood-sucking parasites likely involves communication with their hosts. We find that Ixodes ticks are responsive to IFNg acquired in a blood meal from mice infected with the Lyme disease-causing ... -
HtrA, a Temperature- and Stationary Phase-Activated Protease Involved in Maturation of a Key Microbial Virulence Determinant, Facilitates Borrelia burgdorferi Infection in Mammalian Hosts
Ye, Meiping; Sharma, Kavita; Thakur, Meghna; Smith, Alexis A.; Buyuktanir, Ozlem; Xiang, Xuwu; Pal, Utpal (Amer Soc Microbiology, 2016)High-temperature requirement protease A (HtrA) represents a family of serine proteases that play important roles in microbial biology. Unlike the genomes of most organisms, that of Borrelia burgdorferi notably encodes a ...
