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A Borrelia burgdorferi Surface-Exposed Transmembrane Protein Lacking Detectable Immune Responses Supports Pathogen Persistence and Constitutes a Vaccine Target
Kung, Faith; Kaur, Simarjot; Smith, Alexis A.; Yang, Xiuli; Wilder, Cara N.; Sharma, Kavita; Pal, Utpal (Oxford Univ Press Inc, 2016)Borrelia burgdorferi harbors a limited set of transmembrane surface proteins, most of which constitute key targets of humoral immune responses. Here we show that BB0405, a conserved membrane-spanning protein of unknown ... -
HtrA, a Temperature- and Stationary Phase-Activated Protease Involved in Maturation of a Key Microbial Virulence Determinant, Facilitates Borrelia burgdorferi Infection in Mammalian Hosts
Ye, Meiping; Sharma, Kavita; Thakur, Meghna; Smith, Alexis A.; Buyuktanir, Ozlem; Xiang, Xuwu; Pal, Utpal (Amer Soc Microbiology, 2016)High-temperature requirement protease A (HtrA) represents a family of serine proteases that play important roles in microbial biology. Unlike the genomes of most organisms, that of Borrelia burgdorferi notably encodes a ...