Yazar "Senturk, Murat" için listeleme
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alpha-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters
Cavdar, Huseyin; Ekinci, Deniz; Talaz, Oktay; Saracoglu, Nurullah; Senturk, Murat; Supuran, Claudiu T. (Taylor & Francis Ltd, 2012)Carbonic anhydrases (CA) catalyze activated ester hydrolysis in addition to the hydration of CO 2 to bicarbonate. They also show phosphatase activity with 4-nitrophenyl phosphate as substrate but not sulfatase with the ... -
An Alternative Purification Method for Human Serum Paraoxonase 1 and its Interactions with Sulfonamides
Ekinci, Deniz; Senturk, Murat; Beydemir, Sukru; Kufrevioglu, Omar Irfan; Supuran, Claudiu T. (Wiley-Blackwell, 2010)Paraoxonase 1 (PON1), a high-density lipoprotein (HDL)-associated esterase, is known to mediate antioxidant and antiatherogenic properties. Purification of PON1 has been challenging for a long time. Here, we report a novel ... -
Assesment of metal inhibition of antioxidant enzyme glutathione reductase from rainbow trout liver
Ekinci, Deniz; Senturk, Murat (Taylor & Francis Ltd, 2013)Effects of Co+2, Zn+2, Ca+2, Fe+2, Mn+2, Cr+3, Sn+2 and Mg+2 exposure of rainbow trout liver on the enzymatic activity of glutathione reductase (GR) were investigated. GR was purified from rainbow trout liver 1419-fold ... -
Biological Evaluation of Some Uracil Derivatives as Potent Glutathione Reductase Inhibitors
Guney, Murat; Ekinci, Deniz; Cavdar, Huseyin; Senturk, Murat; Zilbeyaz, Kani (Amer Inst Physics, 2016)Discovery of glutathione reductase (GR) inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, GR inhibitory capacities of some uracil derivatives (UDCs) (1-4) were reported. ... -
Carbonic anhydrase from Apis mellifera: purification and inhibition by pesticides
Soydan, Ercan; Guler, Ahmet; Biyik, Selim; Senturk, Murat; Supuran, Claudiu T.; Ekinci, Deniz (Taylor & Francis Ltd, 2017)Carbonic anhydrase (CA) enzymes have been shown to play an important role in ion transport and in pH regulation in several organisms. Despite this information and the wealth of knowledge regarding the significance of CA ... -
Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives
Fidan, Ismail; Salmas, Ramin Ekhteiari; Arslan, Mehmet; Senturk, Murat; Durdagi, Serdar; Ekinci, Deniz; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2015)The inhibition of two human cytosolic carbonic anhydrase isozymes I and II, with some novel glycine and phenylalanine sulfonamide derivatives were investigated. Newly synthesized compounds G1-4 and P1-4 showed effective ... -
Carbonic anhydrase inhibitors: in vitro inhibition of alpha isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids
Ekinci, Derya; Karagoz, Lutfi; Ekinci, Deniz; Senturk, Murat; Supuran, Claudiu T. (Taylor & Francis Ltd, 2013)A series of flavonoids, such as quercetin, catechin, apigenin, luteolin, morin, were investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA). The compounds were tested against four ... -
Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds
Ekinci, Deniz; Kurbanoglu, Namudar I.; Salamci, Emine; Senturk, Murat; Supuran, Claudiu T. (Taylor & Francis Ltd, 2012)Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as anti-glaucoma agents, diuretics and anti-epileptics. We report here the inhibitory capacities of benzenesulphonamides, cyclitols and phenolic ... -
Carbonic anhydrase inhibitory properties of some uracil derivatives
Turkoglu, Emir Alper; Senturk, Murat; Supuran, Claudiu T.; Ekinci, Deniz (Taylor & Francis Ltd, 2017)Inhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4-12) to inhibit human CA I (hCA I) ... -
Characterization and anions inhibition studies of an alpha-carbonic anhydrase from the teleost fish Dicentrarchus labrax
Ekinci, Deniz; Ceyhun, Saltuk Bugrahan; Senturk, Murat; Erdem, Deryanur; Kufrevioglu, Omer Irfan; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2011)Carbonic anhydrase (CA; EC 4.2.1.1) was purified from the gill of the teleost fish Dicentrarchus labrax (European seabass). The purification procedure consisted of a single step affinity chromatography on Sepharose ... -
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors
Ekinci, Deniz; al-Rashida, Mariya; Abbas, Ghulam; Senturk, Murat; Supuran, Claudiu T. (Taylor & Francis Ltd, 2012)A series of sulfonamide derivatives incorporating substituted 3-formylchromone moieties were investigated for the inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, hCA I, II, and VI. All these ... -
Deltamethrin attenuates antioxidant defense system and induces the expression of heat shock protein 70 in rainbow trout
Ceyhun, Saltuk Bugrahan; Senturk, Murat; Ekinci, Deniz; Erdogan, Orhan; Ciltas, Abdulkadir; Kocaman, Esat Mahmut (Elsevier Science Inc, 2010)The current research aims to determine alterations in gene expression and enzymatic activity of fish antioxidant metabolism in response to pesticide administration. To this end, three different deltamethrin concentrations ... -
Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors
Cakmak, Resit; Durdagi, Serdar; Ekinci, Deniz; Senturk, Murat; Topal, Giray (Pergamon-Elsevier Science Ltd, 2011)Discovery of GR inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, the synthesis and GR inhibitory capacities of novel nitroaromatic compounds (NCs) (1-3) were reported. ... -
Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme
Kocaoglu, Esma; Talaz, Oktay; Cavdar, Huseyin; Senturk, Murat; Supuran, Claudiu T.; Ekinci, Deniz (Taylor & Francis Ltd, 2019)Glutathione reductase (GR) is a crucial antioxidant enzyme which is responsible for the maintenance of antioxidant GSH molecule. Antimalarial effects of some chemical molecules are attributed to their inhibition of GR, ... -
Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II, and VI
Senturk, Murat; Ekinci, Deniz; Goksu, Suleyman; Supuran, Claudiu T. (Taylor & Francis Ltd, 2012)Studies on carbonic anhydrase (CA, EC 4.2.1.1) inhibitors have increased due to several therapeutic applications while there are few investigations on activators. Here we investigated CA inhibitory and activatory capacities ... -
In vitro enzymatic response of Turkish native chicken "Gerze" to heavy metal exposure
Mercan, Levent; Okumus, Ahmet; Senturk, Murat; Ekinci, Deniz (Informa Healthcare, 2013)Glucose-6-phosphate dehydrogenase (G6PD) was purified and characterized from the Turkish native chicken, Gerze, erythrocytes for the first time, and some characteristics were investigated. Purification procedure consisted ... -
Influence of Different Dietary Lipids on the Activity of Metabolic Enzymes in Brown Trout (Salmo trutta)
Atasever, Ali; Arslan, Murat; Sirkecioglu, Necdet; Bayir, Abdulkadir; Ekinci, Deniz; Senturk, Murat (Central Fisheries Research Inst, 2014)The objective of this experiment was to test the effect of different dietary lipids in brown trout feeding on the activity of metabolic enzymes, such as hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD) and ... -
Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies
Cavdar, Huseyin; Senturk, Murat; Guney, Murat; Durdagi, Serdar; Kayik, Gulru; Supuran, Claudiu T.; Ekinci, Deniz (Taylor & Francis Ltd, 2019)Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) inhibitors are interesting compounds for different therapeutic applications, among which Alzheimer's disease. Here, we investigated the inhibition of these ... -
Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds
Balaydin, Halis Turker; Durdagi, Serdar; Ekinci, Deniz; Senturk, Murat; Goksu, Suleyman; Menzek, Abdullah (Taylor & Francis Ltd, 2012)Carbonic anhydrase inhibitors (CAI) are valuable molecules as they have several therapeutic applications, including anti-glaucoma activity. In this study, inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) ...
