Yazar "Salis, Osman" için listeleme
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The anticancer effects of desferrioxamine on human breast adenocarcinoma and hepatocellular carcinoma cells
Salis, Osman; Bedir, Abdulkerim; Kilinc, Veli; Alacam, Hasan; Gulten, Sedat; Okuyucu, Ali (Ios Press, 2014)N-myc downstream-regulated gene 1 (NDRG1) is defined as metastasis suppressor and can be downregulated in many types of cancers, and reported to be an indication of tumor progression in hepatocellular carcinomas. Several ... -
Antimetastatic effect of fluvastatin on breast and hepatocellular carcinoma cells in relation to SGK1 and NDRG1 genes
Salis, Osman; Okuyucu, Ali; Bedir, Abdulkerim; Gor, Ufuk; Kulcu, Canan; Yenen, Eser; Kilic, Nermin (Sage Publications Ltd, 2016)Metastasis occurs due to migration of the cells from primary tumor toward other tissues by gaining invasive properties. Since metastatic invasion shows a strong resistance against conventional cancer treatments, the studies ... -
Clinical significance of glucocorticoid receptor expression in premature infants with respiratory distress syndrome
Ataseven, Fevzi; Salis, Osman; Aygun, Canan; Bedir, Abdulkerim; Kucukoduk, Sukru (Taylor & Francis Ltd, 2017)Objective: Previous studies have shown the relationship between lung development and glucocorticoids, but no studies have been conducted to investigate if a relationship exists between respiratory distress syndrome (RDS) ... -
Cytotoxic Effect of Fluvastatin on MCF-7 Cells Possibly Through a Reduction of the mRNA Expression Levels of SGK1 and CAV1
Salis, Osman; Bedir, Abdulkerim; Gulten, Sedat; Okuyucu, Ali; Kulcu, Canan; Alacam, Hasan (Mary Ann Liebert, Inc, 2014)Fluvastatin (FLU) prevents the conversion of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonic acid by inhibiting HMG-CoA reductase and decreases cholesterol level. Although the effects of FLU treatment on several ... -
Do iron chelators increase the antiproliferative effect of trichostatin A through a glucose-regulated protein 78 mediated mechanism?
Kilinc, Veli; Bedir, Abdulkerim; Okuyucu, Ali; Salis, Osman; Alacam, Hasan; Gulten, Sedat (Sage Publications Ltd, 2014)Histone deacetylase (HDAC) inhibitors, such as trichostatin A (TSA), and iron chelators, including deferoxamine (DFO) and phenanthroline (PHEN), appear to have anticancer effects. We hypothesized that the HDAC inhibitors ... -
Does ADMA affect the oxidant/antioxidant balance in rats?
Alacam, Hasan; Avci, Bahattin; Salis, Osman; Dilek, Ahmet; Kozan, Ahmet; Mertoglu, Cuma; Okuyucu, Ali (Tubitak Scientific & Technical Research Council Turkey, 2013)Aim: Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide synthase (NOS). Oxidative stress might be defined as an imbalance between protein oxidation and antioxidants. Our aim was to determine in vivo whether ... -
The effect of curcumin on lung injuries in a rat model induced by aspirating gastrointestinal decontamination agents
Gunaydin, Mithat; Guzel, Aygul; Guzel, Ahmet; Alacam, Hasan; Salis, Osman; Murat, Naci; Guvenc, Tolga (W B Saunders Co-Elsevier Inc, 2012)Background: Aspiration is one of the most feared complications of gastrointestinal decontamination procedures with nonabsorbed polyethylene glycol (PEG) solution and activated charcoal (AC). We aimed to investigate the ... -
Effect of dexamethasone on unfolded protein response genes (MTJ1, Grp78, Grp94, CHOP, HMOX-1) in HEp2 cell line
Duzgun, Aynur; Bedir, Abdulkerim; Ozdemir, Tulay; Nar, Rukiye; Kilinc, Veli; Salis, Osman; Gulten, Sedat (Natl Inst Science Communication-Niscair, 2013)The endoplasmic reticulum (ER) is related to the various signal routes that are activated in unfolded protein response (UPR). The Grp78, Grp94, CHOP, MTJ1 and HMOX1 genes expressions demonstrate UPR activity. In this study, ... -
Effect of methylphenidate treatment on appetite and levels of leptin, ghrelin, adiponectin, and brain-derived neurotrophic factor in children and adolescents with attention deficit and hyperactivity disorder
Sahin, Serkan; Yuce, Murat; Alacam, Hasan; Karabekiroglu, Koray; Say, Gokce Nur; Salis, Osman (Taylor & Francis Ltd, 2014)Objectives. We aimed to explore whether the use of methylphenidate relates leptin, ghrelin, adiponectin, and brain-derived neurotrophic factor (BDNF). In addition, the relationship between methylphenidate-related weight ... -
The effect of ouabain on mitochondrial DNA damage in HepG2 cell lines
Nar, Rukiye; Bedir, Abdulkerim; Alacam, Hasan; Kilinc, Veli; Avci, Bahattin; Salis, Osman; Gulten, Sedat (Springer, 2012)Our purpose in this study is to analyze mitochondrial DNA (mtDNA) lesion frequencies and mtDNA(4977) deletion in HepG2 cells to examine the effects of ouabain on mtDNA. HepG2 cells were treated with 0.75, 7.5, 75, and 750 ... -
Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia
Erdemli, Haci Kemal; Yildirimlar, Pinar; Alper, Tayfun Yasar; Kocabas, Ramazan; Salis, Osman; Bedir, Abdulkerim (Taylor & Francis Inc, 2014)Objective: To evaluate the utility of serum biomarkers in the diagnosis of preeclampsia (PE) and also investigate possible correlation with pathogenesis of PE. Methods: Maternal serum concentrations of heme oxygenase-1 ... -
Is Serum Caveolin-1 a Useful Biomarker for Progression in Patients with Colorectal Cancer?
Erdemli, Haci Kemal; Kocabas, Ramazan; Salis, Osman; Sen, Fatma; Akyol, Sumeyya; Eskin, Fatih; Sahin, Abdullah Fahri (Clin Lab Publ, 2016)Background: Colorectal cancer (CRC) is the third most common cause of cancer diagnosed in males and the second in females. Survival is strongly related to stage at diagnosis. There is an urgent need to find a noninvasive ... -
Is there any role of epithelial to mesenchymal transition in the pathogenesis of contrast nephropathy?
Sayarlioglu, Hayriye; Okuyucu, Ali; Bedir, Abdulkerim; Salis, Osman; Yenen, Eser; Bekfilavioglu, Garip; Kaya, Coskun (Taylor & Francis Ltd, 2016)Aim: Contrast medium-induced nephropathy is one of the major complications of intravenous contrast medium use. But its pathogenesis is unclear. Epithelial mesenchymal transition (EMT) is defined as the transformation of ... -
Neuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia
Guven, Mustafa; Aras, Adem Bozkurt; Akman, Tarik; Sen, Halil Murat; Ozkan, Adile; Salis, Osman; Cosar, Murat (Mashhad Univ Med Sciences, 2015)Objective(s): Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. Material and Methods: Rats were randomly divided into ... -
Ouabain Targets the Unfolded Protein Response for Selective Killing of HepG2 Cells During Glucose Deprivation
Ozdemir, Tulay; Nar, Rukiye; Kilinc, Veli; Alacam, Hasan; Salis, Osman; Duzgun, Aynur; Bedir, Abdulkerim (Mary Ann Liebert Inc, 2012)Ouabain is a cardiotonic steroid and specific inhibitor of the Na+/K+-ATPase. The relationship between ouabain treatment and the unfolded protein response (UPR) in cells is not precisely understood. Therefore, we studied ... -
The Protective Effect of Ascorbic Acid on Exogenous Asymmetric Dimethylarginine Induced Intimal Thickness and Cholesterol Increase in Rats
Okuyucu, Ali; Salis, Osman; Alici, Omer; Ilkaya, Fatih; Altuntas, Aynur; Guvenli, Abdullah; Alacam, Hasan (Carbone Editore, 2015)Introduction: The endothelium plays an important role in maintaining vascular structure and waits; and endothelial cells are protective against the thrombosis and atherosclerosis. Cardiovascular risk factors, such as ... -
The restorative effect of ascorbic acid on liver injury induced by asymmetric dimethylarginine
Okuyucu, Ali; Salis, Osman; Alici, Omer; Guvenli, Abdullah; Terzi, Yuksel; Keles, Muhammed Emin; Alacam, Hasan (Tubitak Scientific & Technical Research Council Turkey, 2016)We aimed to determine whether increased levels of asymmetric dimethylarginine (ADMA) directly cause hepatic deterioration and whether it is decreased by ascorbic acid (AA) as an antioxidant. The study included three groups: ... -
The Role of Acetylsalicylic Acid as an Assistant Drug in the Management of Hepatocellular Carcinoma
Alacam, Hasan; Bedir, Abdulkerim; Kilinc, Veli; Salis, Osman; Gulten, Sedat (Akad Doktorlar Yayinevi, 2012)Glucose regulated protein 78 (Grp78) is a chaperon which acts in the protein folding. Cell-surface Grp78 is present on the surface of different type cancer cells. There are evidences that acetylsalicylic acid (ASA) provides ... -
The role of iNOS inhibitors on lung injury induced by gastrointestinal decontamination agents aspiration
Guzel, Ahmet; Guzel, Aygul; Gunaydin, Mithat; Alacam, Hasan; Salis, Osman; Paksu, M. Sukru; Guvenc, Tolga (Springer, 2012)Aspiration is a devastating complication during decontamination procedure in poisoning patients. We have investigated whether S-methylisothiourea protects different pulmonary aspiration gastrointestinal decontamination ...
