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Effect of dexamethasone on unfolded protein response genes (MTJ1, Grp78, Grp94, CHOP, HMOX-1) in HEp2 cell line
Duzgun, Aynur; Bedir, Abdulkerim; Ozdemir, Tulay; Nar, Rukiye; Kilinc, Veli; Salis, Osman; Gulten, Sedat (Natl Inst Science Communication-Niscair, 2013)The endoplasmic reticulum (ER) is related to the various signal routes that are activated in unfolded protein response (UPR). The Grp78, Grp94, CHOP, MTJ1 and HMOX1 genes expressions demonstrate UPR activity. In this study, ... -
Is median value of Double Screening Test regional?
Erdemli, Haci Kemal; Kocabas, Ramazan; Ozdemir, Tulay; Bedir, Abdulkerim (Walter De Gruyter Gmbh, 2015)Objective: The median values of double test which is commonly used for Down Syndrome screening show diversity between countries. In this study, we aimed to investigate the possible differences in corrected multiplies of ... -
Ouabain Targets the Unfolded Protein Response for Selective Killing of HepG2 Cells During Glucose Deprivation
Ozdemir, Tulay; Nar, Rukiye; Kilinc, Veli; Alacam, Hasan; Salis, Osman; Duzgun, Aynur; Bedir, Abdulkerim (Mary Ann Liebert Inc, 2012)Ouabain is a cardiotonic steroid and specific inhibitor of the Na+/K+-ATPase. The relationship between ouabain treatment and the unfolded protein response (UPR) in cells is not precisely understood. Therefore, we studied ...