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Genetic engineering of an industrial strain of Streptomyces clavuligerus for further enhancement of clavulanic acid production
Kurt Kizildogan, Aslihan; Vanli Jaccard, Guliz; Mutlu, Alper; Sertdemir, Ibrahim; Ozcengiz, Gulay (Tubitak Scientific & Technical Research Council Turkey, 2017)An industrial clavulanic acid (CA) overproducer Streptomyces clavuligerus strain, namely DEPA, was engineered to further enhance its CA production. Single or multiple copies of ccaR, claR (pathway-specific activators), and ...
