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A Borrelia burgdorferi Surface-Exposed Transmembrane Protein Lacking Detectable Immune Responses Supports Pathogen Persistence and Constitutes a Vaccine Target
Kung, Faith; Kaur, Simarjot; Smith, Alexis A.; Yang, Xiuli; Wilder, Cara N.; Sharma, Kavita; Pal, Utpal (Oxford Univ Press Inc, 2016)Borrelia burgdorferi harbors a limited set of transmembrane surface proteins, most of which constitute key targets of humoral immune responses. Here we show that BB0405, a conserved membrane-spanning protein of unknown ... -
Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection
Yang, Xiuli; Lin, Yi-Pin; Heselpoth, Ryan D.; Buyuktanir, Ozlem; Qin, Jinhong; Kung, Faith; Pal, Utpal (Wiley, 2016)Borrelia burgdorferi surface-located membrane protein 1, also known as Lmp1, has been shown to play critical roles in pathogen evasion of host-acquired immune defences, thereby facilitating persistent infection. Lmp1 ...