Yazar "Kozan, Ramazan" için listeleme
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Akut ve kronik alkol alan sıçanlarda penisilinle oluşturulan epileptiform aktiviteye vitamin E'nin etkisi / Ramazan Kozan; Danışman Erdal Ağar
Kozan, Ramazan (Ondokuz Mayıs Üniversitesi, Tıp Fakultesi, 2007)… -
Anticonvulsant effect of carnosine on penicillin-induced epileptiform activity in rats
Kozan, Ramazan; Sefil, Fatih; Bagirici, Faruk (Elsevier Science Bv, 2008)Carnosine is a compound of naturally-occurring dipeptide that synthesized by the carnosine synthetase from beta-alanine and L-histidine. Recent reports claim that carnosine plays an important role in the control of epilepsy ... -
Bilateral high frequency stimulation of the subthalamic nucleus normalizes COX activity in the substantia nigra of Parkinsonian rats
Vlamings, Rinske; Visser-Vandewalle, Veerle; Kozan, Ramazan; Kaplan, Süleyman; Steinbusch, Harry W. M.; Temel, Yasin (Elsevier Science Bv, 2009)Part of the mechanism underlying the therapeutic effect of subthalamic nucleus (STN) high frequency stimulation (HFS) involves the activity of the basal ganglia output structures. The general idea is that STN's burst ... -
Demirin neden olduğu purkinje hücre kaybı üzerine nitrik oksit sentaz inhibisyonunun koruyucu etkisi
Amaç: Demir, nöronal hiperaktivite ve oksidatif stresi indüklemek için sıklıkla kullanılan bir metaldir. Nitrik oksit sentaz (NOS) tarafından sentezlenen nitrik oksit ile hücre ölümü arasındaki ilişkiyi ortaya koyan bulgular ... -
The effect of alpha-tocopherol in the acute ethanol intake and its withdrawal on penicillin-induced epilepsy
Kozan, Ramazan; Ayyildiz, Mustafa; Yildirim, Mehmet; Agar, Erdal (Nencki Inst Experimental Biology, 2009)The present study was designed to investigate the influence of acute ethanol intake and its withdrawal on the anticonvulsant effect of alpha-tocopherol in penicillin-induced epileptiform activity. Ethanol-treated rats ... -
The effects of ethanol intake and withdrawal on penicillin-induced epileptiform activity in rats
Kozan, Ramazan; Ayyildiz, Mustafa; Yildirim, Mehmet; Agar, Erdal (Pergamon-Elsevier Science Ltd, 2006)Previous experiments have shown that ethanol may have either pro-convulsive or anti-convulsive effects on epileptic activity in different experimental epilepsy models. In this study, the effect of low dose ethanol and its ... -
The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats
Kozan, Ramazan; Ayyildiz, Mustafa; Agar, Erdal (Wiley, 2009)P>Purpose: Several results support the conclusion that the cannabinoid system has a role in generation and cessation of epileptic seizures. The aim of this study was to evaluate the effects of intracerebroventricular AM-251 ... -
The influence of ethanol intake and its withdrawal on the anticonvulsant effect of alpha-tocopherol in the penicillin-induced epileptiform activity in rats
Kozan, Ramazan; Ayyildiz, Mustafa; Yildirim, Mehmet; Agar, Erdal (Elsevier, 2007)Previous studies proposed the existence of a relationship between epilepsy and ethanol. Ethanol may have either proconvulsive or anticonvulsive effects on epileptic activity in different experimental epilepsy models. The ... -
Inhibition of neuronal nitric oxide synthase prevents iron-induced cerebellar Purkinje cell loss in the rat
Gulturk, Sefa; Kozan, Ramazan; Bostanci, M. Omer; Sefil, Fatih; Bagirici, Faruk (Nencki Inst Experimental Biology, 2008)Iron plays an important role in maintaining normal. brain function. However, in many neurodegenerative diseases abnormal iron accumulation in specific brain regions has been consistently reported. In this study, we ... -
Interaction between carbenoxolone and valproic acid on pentylenetetrazole kindling model of epilepsy
Sefil, Fatih; Arik, Aliye E.; Acar, Meryem D.; Bostanci, Mehmet O.; Bagirici, Faruk; Kozan, Ramazan (E-Century Publishing Corp, 2015)Gap junctions play an important role in the synchronized neuronal discharges. The main reason of the epileptic seizures is disruption of this synchronization. Therefore, the aim of the present study is to explore the ... -
Iron-Induced Cerebellar Purkinje Cell Loss Is Ameliorated by Flunarizine
Kozan, Ramazan; Bostanci, M. Oemer; Nacar, Tuncer; Aslan, Ali; Bagirici, Faruk (Tubitak Scientific & Technical Research Council Turkey, 2009)Aim: In this study, we investigated the effect of intracerebroventricular-injected iron neurotoxicity on the total number of cerebellar Purkiinje cells in rats and the possible neuroprotective effect of flunarizine, a ... -
Nitric oxide synthase inhibitors protect cerebellar Purkinje cells from zinc-induced cell loss in adult rat
Gokce, Mehmet Fatih; Kaplan, Süleyman; Turkkani, Ayten; Kozan, Ramazan; Ayyildiz, Mustafa; Emirzeoglu, Mehmet; Marangoz, Cafer (Elsevier Science Bv, 2011)Zinc is an important trace element in biological systems; however, excessive extracellular zinc could lead to neuronal cell death following ischemia, seizures, and brain trauma. In this study, we investigated whether the ... -
Protection of nigral cell death by bilateral subthalamic nucleus stimulation
Temel, Yasin; Visser-Vandewalle, Veerle; Kaplan, Süleyman; Kozan, Ramazan; Daemen, Marc A. R. C.; Blokland, Arjan; Steinbusch, Harry W. M. (Elsevier Science Bv, 2006)In Parkinson disease (PD), the subthalamic nucleus (STN) becomes hyperactive (disinhibited), which is reported to cause excitotoxic damage to midbrain dopaminergic neurons. Here, we examined whether silencing of the ... -
Sexual dimorphism in the medial vestibular nucleus of adult rats: Stereological study
Ayyildiz, Mustafa; Kozan, Ramazan; Agar, Erdal; Kaplan, Süleyman (Springer, 2008)The vestibular system helps the body to maintain equilibrium. There are four vestibular nuclei on the right and left sides, the medial vestibular nucleus being the largest. The volumes and total numbers of neurons in the ... -
Short-term ethanol administration does not change the total pyramidal neuron number of the rat hippocampus: A stereologic study
Kozan, Ramazan; Ayyildiz, Mustafa; Bas, Orhan; Kaplan, Süleyman; Agar, Erdal (Springer, 2007)In the hippocampus, short-term exposure to ethanol (EtOH) has been shown to inhibit some functions, and nitric oxide (NO) is an important modulator of physiologic processes. in this study, investigators explored the effects ... -
Sıçan serebellumunda demir nörotoksisitesine karşı vitamin E'nin koruyucu etkisi
Amaç: Bu çalışmada, intraserebroventriküler olarak verilen demirin, sıçan serebellar Purkinje hücrelerinde oluşturduğu nörotoksisiteye karşı yağda çözülebilen güçlü bir antioksidan olan vitamin E'nin (?-tokoferol) etkisini ...
