Yazar "Kilinc, Veli" için listeleme
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The anticancer effects of desferrioxamine on human breast adenocarcinoma and hepatocellular carcinoma cells
Salis, Osman; Bedir, Abdulkerim; Kilinc, Veli; Alacam, Hasan; Gulten, Sedat; Okuyucu, Ali (Ios Press, 2014)N-myc downstream-regulated gene 1 (NDRG1) is defined as metastasis suppressor and can be downregulated in many types of cancers, and reported to be an indication of tumor progression in hepatocellular carcinomas. Several ... -
Do iron chelators increase the antiproliferative effect of trichostatin A through a glucose-regulated protein 78 mediated mechanism?
Kilinc, Veli; Bedir, Abdulkerim; Okuyucu, Ali; Salis, Osman; Alacam, Hasan; Gulten, Sedat (Sage Publications Ltd, 2014)Histone deacetylase (HDAC) inhibitors, such as trichostatin A (TSA), and iron chelators, including deferoxamine (DFO) and phenanthroline (PHEN), appear to have anticancer effects. We hypothesized that the HDAC inhibitors ... -
Effect of creatine and pioglitazone on Hk-2 cell line cisplatin nephrotoxicity
Genc, Gurkan; Kilinc, Veli; Bedir, Abdulkerim; Ozkaya, Ozan (Taylor & Francis Ltd, 2014)Cisplatin is a chemotherapeutic agent, which is used in the treatment of various solid organ cancers, and its main dose limiting side effect of cisplatin is nephrotoxicity. The aim of this study is to investigate the role ... -
Effect of dexamethasone on unfolded protein response genes (MTJ1, Grp78, Grp94, CHOP, HMOX-1) in HEp2 cell line
Duzgun, Aynur; Bedir, Abdulkerim; Ozdemir, Tulay; Nar, Rukiye; Kilinc, Veli; Salis, Osman; Gulten, Sedat (Natl Inst Science Communication-Niscair, 2013)The endoplasmic reticulum (ER) is related to the various signal routes that are activated in unfolded protein response (UPR). The Grp78, Grp94, CHOP, MTJ1 and HMOX1 genes expressions demonstrate UPR activity. In this study, ... -
The effect of ouabain on mitochondrial DNA damage in HepG2 cell lines
Nar, Rukiye; Bedir, Abdulkerim; Alacam, Hasan; Kilinc, Veli; Avci, Bahattin; Salis, Osman; Gulten, Sedat (Springer, 2012)Our purpose in this study is to analyze mitochondrial DNA (mtDNA) lesion frequencies and mtDNA(4977) deletion in HepG2 cells to examine the effects of ouabain on mtDNA. HepG2 cells were treated with 0.75, 7.5, 75, and 750 ... -
Ouabain Targets the Unfolded Protein Response for Selective Killing of HepG2 Cells During Glucose Deprivation
Ozdemir, Tulay; Nar, Rukiye; Kilinc, Veli; Alacam, Hasan; Salis, Osman; Duzgun, Aynur; Bedir, Abdulkerim (Mary Ann Liebert Inc, 2012)Ouabain is a cardiotonic steroid and specific inhibitor of the Na+/K+-ATPase. The relationship between ouabain treatment and the unfolded protein response (UPR) in cells is not precisely understood. Therefore, we studied ... -
The Role of Acetylsalicylic Acid as an Assistant Drug in the Management of Hepatocellular Carcinoma
Alacam, Hasan; Bedir, Abdulkerim; Kilinc, Veli; Salis, Osman; Gulten, Sedat (Akad Doktorlar Yayinevi, 2012)Glucose regulated protein 78 (Grp78) is a chaperon which acts in the protein folding. Cell-surface Grp78 is present on the surface of different type cancer cells. There are evidences that acetylsalicylic acid (ASA) provides ...
