Yazar "Ilkaya, Fatih" için listeleme
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After myringotomy, can topical Mesna application be an alternative method to ventilation tube application?
Karli, Rifat; Ilkaya, Fatih; Karli, Arzu; Gunbey, Emre; Kucuk, Harun; Guzel, Hasan; Ayhan, Emre (Springer, 2015)Sodium-2-mercaptoethanesulfonate (Mesna) is a mucolytic substance that is also used for chemically assisted tissue dissection in otological surgery. We investigated the effects of Mesna as a chemical agent on the closing ... -
Antidepressant-like effects of echo-planar magnetic resonance imaging in mice determined using the forced swimming test
Aksoz, Elif; Aksoz, Tolga; Bilge, S. Sirri; Ilkaya, Fatih; Celik, Suleyman; Diren, H. Baris (Elsevier, 2008)Echo-planar magnetic resonance imaging (EP-MRI), which is novel variant of MRI, is thought to have antidepressant properties in humans and animal models. Using the forced swimming test (FST), we investigated which monoaminergic ... -
The antinociceptive effect of intravenous imipramine in colorectal distension-induced visceral pain in rats: the role of serotonergic and noradrenergic receptors
Ilkaya, Fatih; Bilge, S. Sirri; Bozkurt, Ayhan; Bas, Duygu B.; Erdal, Arzu; Ciftcioglu, Engin; Kesim, Yuksel (Pergamon-Elsevier Science Ltd, 2014)It has been shown that imipramine, a tricyclic antidepressant (TCA), is a potent analgesic agent. However, the effect of imipramine on visceral pain has not been extensively investigated. In the current study, our aim was ... -
The Antinociceptive Effects of Intravenous Dexmedetomidine in Colorectal Distension-Induced Visceral Pain in Rats: the Role of Opioid Receptors
Ulger, Fatma; Bozkurt, Ayhan; Bilge, S. Sirri; Ilkaya, Fatih; Dilek, Ahmet; Bostanci, M. Oemer; Guldogus, Fuat (Lippincott Williams & Wilkins, 2009)BACKGROUND: In comparison with cutaneous pain, the role of alpha(2)-adrenoceptor (alpha(2)-AR) agonists in visceral pain has not been extensively examined. We aimed to characterize the antinociceptive effect of IV ... -
The antinociceptive effects of intravenous tianeptine in colorectal distension-induced visceral pain in rats: the role of 5-HT3 receptors
Bilge, S. Sirri; Bozkurt, Ayhan; Ilkaya, Fatih; Ciftcioglu, Engin; Kesim, Yuksel; Uzbay, Tayfun I. (Elsevier, 2012)Tianeptine is an unusual tricyclic antidepressant drug. In this study, we aimed to investigate the antinociceptive effect of tianeptine on visceral pain in rats and to determine whether possible antinociceptive effect of ... -
Can empirical hypertonic saline or sodium bicarbonate treatment prevent the development of cardiotoxicity during serious amitriptyline poisoning? Experimental research
Paksu, Muhammet Sukru; Zengin, Halit; Ilkaya, Fatih; Paksu, Sule; Guzel, Hasan; Ucar, Durmus; Guzel, Ahmet (Clinics Cardive Publ Pty Ltd, 2015)Objective: The aim of this experimental study was to investigate whether hypertonic saline or sodium bicarbonate administration prevented the development of cardiotoxicity in rats that received toxic doses of amitriptyline. ... -
Chestnut Honey and Sherbet Enhance the Healing of Burn Wounds in Rat Model
Meteoglu, Irem; Kavas, Nazli C.; Saricaoglu, Muge; Ilkaya, Fatih; Guzel, Hasan; Alici, Omer; Ozturk, Ferhat (Canadian Soc Clinical Investigation, 2015)Purpose: Honey has been used throughout the history both as a food and a therapeutic product due to its nutritional value and its bioactivity. The honeys with high bioactivity are used by complementary medicine practitioners ... -
Chronic treatment with fluoxetine and sertraline prevents forced swimming test-induced hypercontractility of rat detrusor muscle
Bilge, Sirri; Bozkurt, Ayhan; Basl, Duygu B.; Aksoz, Elif; Savli, Evren; Ilkaya, Fatih; Kesim, Yuksel (Polish Acad Sciences Inst Pharmacology, 2008)Serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors represent important targets for the development of new treatments for detrusor overactivity and urinary incontinence. The present study was undertaken to investigate ... -
Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain
Baskin, Veysel; Bilge, S. Sirri; Bozkurt, Ayhan; Akyuz, Bahar; Agri, Arzu Erdal; Guzel, Hasan; Ilkaya, Fatih (Medknow Publications & Media Pvt Ltd, 2016)Objectives: To investigate nonsteroidal anti-inflammatory drugs effectiveness in colorectal distension (CRD)-induced visceral pain model. Materials and Methods: Male Sprague-Dawley (250-300 g) rats were anesthetized with ... -
Effect of prenatal levetiracetam exposure on motor and cognitive functions of rat offspring
Ozyurek, Hamit; Bozkurt, Ayhan; Bilge, Sirri; Ciftcioglu, Engin; Ilkaya, Fatih; Bas, Duygu Belkis (Elsevier Science Bv, 2010)Purpose. We aimed to establish the physical, motor, and cognitive teratogenic effect of levetiracetam exposure throughout pregnancy in rats. Methods. Thirty-two Sprague Dawley pregnant female rats were divided into four ... -
Effects of Paroxetine on Cutaneous Wound Healing in Healthy and Diabetic Rats
Yuksel, Esra Pancar; Ilkaya, Fatih; Yildiz, Levent; Aydin, Fatma; Senturk, Nilgun; Denizli, Hilal; Turanli, Ahmet Yasar (Lippincott Williams & Wilkins, 2014)OBJECTIVE: The aim of this study was to evaluate the histologic effects of acute paroxetine administration on wound healing in healthy and streptozotocin-induced diabetic rats. DESIGN: This study has a randomized controlled ... -
Evaluation of Acute Poisonings in Geriatric Patients Attended To A University Emergency Clinic
Kati, Celal; Karakus, Akan; Altuntas, Mehmet; Duran, Latif; Ilkaya, Fatih; Kaya, Coskun; Yavuz, Yucel (Gunes Kitabevi Ltd Sti, 2013)Introduction: The elderly population is rapidly growing in Turkey and in the world. The aim of our study is to investigate the features of acute poisonings which is a major health problem among the elderly. Materials and ... -
The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch
Ilkaya, Fatih; Yesilyurt, Ozgur; Seyrek, Melik; Gunduz, Ozgur; Ide, Tayfun; Akar, Ahmet; Gunaydin, Caner (Nencki Inst Experimental Biology, 2016)Intradermal injection of pruritogens such as serotonin, histamine and compound 48/80 into the skin and then, the evaluation of the scratching behavior is the commonly used animal model to advance pruritic research and drug ... -
A histomorphometric study regarding controversial effects of antidepressants on bone mineral density in menopause
Ozdes, Emel Kurtoglu; Altunkaynak, Berrin Zuhal; Ilkaya, Fatih; Tosun, Fevziye Canbaz; Kivrak, Elfide Gizem; Onger, Mehmet Emin; Kaplan, Süleyman (E-Century Publishing Corp, 2016)This study investigated the effects of amitriptyline (AMP) and paroxetine (PRO) on bone mineral density and histo-morphometrical structure using an ovariectomized (OVX) rat model. A total of 24 adult female Sprague Dawley ... -
Improving Effect of Atomoxetine and Reboxetine on Memory in Passive Avoidance Task
Yuce, Murat; Ilkaya, Fatih; Karabekiroglu, Koray; Say, Gokce Nur; Mujdeci, Mahmut; Bayril, Filiz; Aydin, Faruk (Kure Iletisim Grubu A S, 2014)Objective: The effects of serotonin and/or noradrenaline re-uptake inhibitors on memory have been investigated in various clinical and pre-clinical studies. However, contradictory results have been reported. In this study, ... -
Opioid Receptors Contribute to Antinociceptive Effect of Tianeptine on Colorectal Distension-Induced Visceral Pain in Rats
Bilge, S. Sirri; Ilkaya, Fatih; Darakci, Ozge; Ciftcioglu, Engin; Bozkurt, Ayhan (Karger, 2018)Tianeptine is a clinically effective atypical antidepressant with distinct neurochemical properties. In this study, we aimed to investigate the contribution of opioid receptors in the antinociceptive effect of tianeptine ... -
Pre-Emptive Analgesic Effects of Tramadol, St. John'S Wort, and Panax Ginseng Extract in Mice
Kaya, Cengiz; Ustun, Yasemin Burcu; Ilkaya, Fatih; Koksal, Ersin (Carbone Editore, 2014)Aim: Pre-emptive analgesia, has been popularised by demonstration of its important decremental effects on the severity and duration of pain. Our aim was to evaluate the pre-emptive analgesic efficacies of St. Johns Wort ... -
The Protective Effect of Ascorbic Acid on Exogenous Asymmetric Dimethylarginine Induced Intimal Thickness and Cholesterol Increase in Rats
Okuyucu, Ali; Salis, Osman; Alici, Omer; Ilkaya, Fatih; Altuntas, Aynur; Guvenli, Abdullah; Alacam, Hasan (Carbone Editore, 2015)Introduction: The endothelium plays an important role in maintaining vascular structure and waits; and endothelial cells are protective against the thrombosis and atherosclerosis. Cardiovascular risk factors, such as ...
