Yazar "Gunes, Sezgin" için listeleme
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Analysis of vitamin D receptor gene polymorphisms in patients with chronic periodontitis
Gunes, Sezgin; Sumer, A. Pinar; Keles, Gonca Cayir; Kara, Nurten; Koprulu, Hulya; Bagci, Hasan; Bek, Yuksel (Medknow Publications & Media Pvt Ltd, 2008)Background & objectives: Genetic polymorphisms in the vitamin D receptor (VDR) gene are related to bone mineral density, bone turnover, and diseases with bone loss. Alveolar bone loss is a key feature in periodontitis. The ... -
ApaL1 urokinase and Taq1 vitamin D receptor gene polymorphisms in first-stone formers, recurrent stone formers, and controls in a Caucasian population
Aykan, Serdar; Tuken, Murat; Gunes, Sezgin; Akin, Yigit; Ozturk, Murat; Seyhan, Serkan; Nguyen, Daniel P. (Springer, 2016)The purpose of this study was to determine differences in genotype distribution and allele frequency of urokinase and vitamin D receptor (VDR) single nucleotide polymorphisms (SNPs) between first-stone formers, recurrent ... -
Association of Abl interactor 2, ABI2, with platelet/lymphocyte ratio in patients with renal cell carcinoma: A pilot study
Ergun, Sercan; Gunes, Sezgin; Buyukalpelli, Recep; Aydin, Oguz (Wiley, 9999)There are many unknown aspects of the pathogenesis of renal cell carcinoma (RCC). The aim of the current study was to define new RCC-related genes and measure their associations with RCC and clinical parameters, especially ... -
Association of eNOS gene polymorphism (Glu298Asp) with psoriasis
Senturk, Nilgun; Kara, Nurten; Aydin, Fatma; Gunes, Sezgin; Yuksel, Esra Pancar; Bagci, Hasan; Turanli, Ahmet Yasar (Elsevier Ireland Ltd, 2006)… -
Association of interleukin-10 gene polymorphisms with severe generalized chronic periodontitis
Sumer, A. Pinar; Kara, Nurten; Keles, Gonca Cayir; Gunes, Sezgin; Koprulu, Hulya; Bagci, Hasan (Wiley, 2007)Background: Interleukin-10 (IL-10), an anti-inflammatory cytokine, plays a role in periodontal disease by inhibiting synthesis of proinflammatory cytokines and stimulating protective antibody production. Genetic polymorphisms ... -
Association of matrix metalloproteinase-9 promoter gene polymorphism with chronic periodontitis
Keles, Gonca Cayir; Gunes, Sezgin; Sumer, A. Pinar; Sumer, Mahmut; Kara, Nurten; Bagci, Hasan; Koprulu, Hulya (Wiley, 2006)Background: Matrix metalloproteinases (MMPs) are related to tissue destruction and remodeling events in periodontal diseases. A single nucleotide polymorphism in the promoter region of human MMP-9 gene is associated with ... -
Association of serotonin 2A receptor and lack of association of CYP1A2 gene polymorphism with tardive dyskinesia in a Turkish population
Boke, Omer; Gunes, Sezgin; Kara, Nurten; Aker, Servet; Sahin, Ahmet Rifat; Basar, Yildiz; Bagci, Hasan (Mary Ann Liebert, Inc, 2007)The aim of this study was to investigate the possible association of serotonin 2A receptor gene (HTR2A) - 1438 G/A polymorphism and CYP1A2 gene 163C/ A polymorphism with tardive dyskinesia (TD) in a Turkish population. A ... -
Association of transforming growth factor beta 1 gene polymorphism with rheumatoid arthritis in a Turkish population
Alayli, Gamze; Kara, Nurten; Tander, Berna; Canturk, Ferhan; Gunes, Sezgin; Bagci, Hasan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2009)Objective: Cytokine genes play important role, in the pathogenesis of rheumatoid arthritis (RA). In RA, the plasma and synovial fluid levels of transforming growth factor beta 1 (TGF beta 1) have been shown to be raised. ... -
Chromosomal and Y-chromosome microdeletion analysis in 1,300 infertile males and the fertility outcome of patients with AZFc microdeletions
Abur, Ummet; Gunes, Sezgin; Asci, Ramazan; Altundag, Engin; Akar, Omer S.; Ayas, Bulent; Ogur, Gonul (Wiley, 2019)The present study investigated the frequency of chromosome aberrations and AZF microdeletions in infertile patients with nonobstructive azoospermia (NOA) or severe oligozoospermia. Additionally, the effect of the AZFc ... -
CYP1A2, CYP2D6, GSTM1, GSTP1, and GSTT1 gene polymorphisms in patients with bladder cancer in a Turkish population
Altayli, Ertan; Gunes, Sezgin; Yilmaz, Ali Faik; Goktas, Serdar; Bek, Yuksel (Springer, 2009)Genetic differences in the metabolism of xenobiotics have recently been suggested as modifiers of individual susceptibility to bladder cancer (BC). The objective of this study was to investigate the relationship between ... -
Disruption of HDX gene in premature ovarian failure
Okten, Gulsen; Gunes, Sezgin; Onat, Onur Emre; Tukun, Ajlan; Ozcelik, Tayfun; Kocak, Idris (Taylor & Francis Inc, 2013)We present a case of a 19-year-old phenotypically normal girl with premature ovarian failure. Cytogenetic analysis using G banding and fluorescence in situ hybridization (FISH) from cultured peripheral blood lymphocytes ... -
Effects of aging on the male reproductive system
Gunes, Sezgin; Hekim, Gulgez Neslihan Taskurt; Arslan, Mehmet Alper; Asci, Ramazan (Springer/Plenum Publishers, 2016)The study aims to discuss the effects of aging on the male reproductive system. A systematic review was performed using PubMed from 1980 to 2014. Aging is a natural process comprising of irreversible changes due to a myriad ... -
ErbB receptor tyrosine kinase family expression levels in urothelial bladder carcinoma
Gunes, Sezgin; Sullu, Yurdanur; Yegin, Zeynep; Buyukalpelli, Recep; Tomak, Leman; Bagci, Hasan (Elsevier Gmbh, 2013)ErbB receptor tyrosine kinases family plays an important role in cell cycle regulation. Overexpression of ErbB receptors has been described in several solid tumors. The aim of this study was to investigate the levels of ... -
Fibular aplasia, tibial campomelia, and oligosyndactyly: a further patient with a 2-year follow-up
Sezer, Ozlem; Gebesoglu, Ismet; Yuan, Bo; Karaca, Ender; Gokce, Erkan; Gunes, Sezgin (Lippincott Williams & Wilkins, 2014)… -
Glutamate transporter SLC1A1 is associated with clear cell renal cell carcinoma
Ergun, Sercan; Gunes, Sezgin; Buyukalpelli, Recep; Aydin, Oguz (Tubitak Scientific & Technical Research Council Turkey, 2019)Background/aim: This study aimed to comparatively analyze the expression levels of the SLC1A1 gene in renal specimens from tumors and adjacent healthy kidney tissues of patients with clear cell renal cell carcinoma (ccRCC). ... -
Hypermethylation of TWIST1 and NID2 in Tumor Tissues and Voided Urine in Urinary Bladder Cancer Patients
Yegin, Zeynep; Gunes, Sezgin; Buyukalpelli, Recep (Mary Ann Liebert, Inc, 2013)Bladder cancer like other cancers arises from the accumulation of many genetic and epigenetic changes that lead to the activation of proto-oncogenes or inactivation of tumor suppressor genes. We aimed to investigate the ... -
Investigating the relationship between BRCA1 and BRCA2 genes methylation profile and sperm DNA fragmentation in infertile men
Kabartan, Emel; Gunes, Sezgin; Arslan, Mehmet Alper; Asci, Ramazan (Wiley, 2019)The purpose of the study was to investigate whether the promoter methylation status of BRCA1 and BRCA2 DNA repair genes is associated with sperm DNA fragmentation (sDF) in infertile men with oligoasthenoteratozoospermia ... -
Lack of association between the G-2548A polymorphism of the leptin gene and psoriasis in a Turkish population
Kara, Nurten; Aydin, Fatma; Senturk, Nilgun; Gunes, Sezgin; Canturk, M. Tayyar; Bagci, Hasan; Turanli, Ahmet Yasar (Blackwell Publishing, 2007)Background Psoriasis is a multifactorial disease in which genetic and inflammatory factors play important roles. Leptin is classified as a cytokine and plays an important role in the regulation of the T-helper response. A ... -
Microtubular Dysfunction and Male Infertility
Gunes, Sezgin; Sengupta, Pallav; Henkel, Ralf; Alguraigari, Aabed; Sinigaglia, Mariana Marques; Kayal, Malik; Agarwal, Ashok (Pusan Natl Univ Medical Sch, Dept Urology, 2020)Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain ... -
De Novo Balanced (X;14) Translocation in a Patient with Recurrent Miscarriages: Case Report
Pinarli, Ferda Alpaslan; Okten, Gulsen; Ozcelik, Tayfun; Kara, Nurten; Gunes, Sezgin; Kocak, Idris (Ortadogu Ad Pres & Publ Co, 2011)We report a 23-year-old phenotypically normal female patient who had previously suffered from recurrent spontaneous abortion (RSA) who found to have an X;14 trans location and a Methylene- Tetrahdrofolate-Reductase (MTHFR) ...
