Yazar "Gulten, Sedat" için listeleme
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The anticancer effects of desferrioxamine on human breast adenocarcinoma and hepatocellular carcinoma cells
Salis, Osman; Bedir, Abdulkerim; Kilinc, Veli; Alacam, Hasan; Gulten, Sedat; Okuyucu, Ali (Ios Press, 2014)N-myc downstream-regulated gene 1 (NDRG1) is defined as metastasis suppressor and can be downregulated in many types of cancers, and reported to be an indication of tumor progression in hepatocellular carcinomas. Several ... -
Assessment of different folic acid supplementation doses for low-birth-weight infants
Celik, Fatma Cakmak; Aygun, Canan; Gulten, Sedat; Bedir, Abdulkerim; Cetinoglu, Erhan; Kucukdoduk, Sukru; Bek, Yuksel (Turkish Pediatrics Assoc, 2016)Aim: The adequacy of 50 mcg folic acid supplementation given to low-birth-weight babies was investigated. The folate levels of the mothers and infants, and breastmilk, and the optimum dose for folic acid supplementation ... -
Cytotoxic Effect of Fluvastatin on MCF-7 Cells Possibly Through a Reduction of the mRNA Expression Levels of SGK1 and CAV1
Salis, Osman; Bedir, Abdulkerim; Gulten, Sedat; Okuyucu, Ali; Kulcu, Canan; Alacam, Hasan (Mary Ann Liebert, Inc, 2014)Fluvastatin (FLU) prevents the conversion of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonic acid by inhibiting HMG-CoA reductase and decreases cholesterol level. Although the effects of FLU treatment on several ... -
Do iron chelators increase the antiproliferative effect of trichostatin A through a glucose-regulated protein 78 mediated mechanism?
Kilinc, Veli; Bedir, Abdulkerim; Okuyucu, Ali; Salis, Osman; Alacam, Hasan; Gulten, Sedat (Sage Publications Ltd, 2014)Histone deacetylase (HDAC) inhibitors, such as trichostatin A (TSA), and iron chelators, including deferoxamine (DFO) and phenanthroline (PHEN), appear to have anticancer effects. We hypothesized that the HDAC inhibitors ... -
Effect of dexamethasone on unfolded protein response genes (MTJ1, Grp78, Grp94, CHOP, HMOX-1) in HEp2 cell line
Duzgun, Aynur; Bedir, Abdulkerim; Ozdemir, Tulay; Nar, Rukiye; Kilinc, Veli; Salis, Osman; Gulten, Sedat (Natl Inst Science Communication-Niscair, 2013)The endoplasmic reticulum (ER) is related to the various signal routes that are activated in unfolded protein response (UPR). The Grp78, Grp94, CHOP, MTJ1 and HMOX1 genes expressions demonstrate UPR activity. In this study, ... -
The effect of ouabain on mitochondrial DNA damage in HepG2 cell lines
Nar, Rukiye; Bedir, Abdulkerim; Alacam, Hasan; Kilinc, Veli; Avci, Bahattin; Salis, Osman; Gulten, Sedat (Springer, 2012)Our purpose in this study is to analyze mitochondrial DNA (mtDNA) lesion frequencies and mtDNA(4977) deletion in HepG2 cells to examine the effects of ouabain on mtDNA. HepG2 cells were treated with 0.75, 7.5, 75, and 750 ... -
Glucocorticoid Receptor-beta Is Downregulated by Vitamin D Treatment in Children with Low Vitamin D Levels but Not in Allergic Asthma
Guner, Sukru Nail; Sancak, Recep; Gulten, Sedat; Ozen, Ahmet; Kilic, Mehtap; Bedir, Abdulkerim (Mary Ann Liebert, Inc, 2015)Background: Vitamin D (VitD) enhances the anti-inflammatory effects of glucocorticoids (GC) in vitro. It was hypothesized that VitD3 (colecalciferol) treatment could have an impact on the expression of glucocorticoid ... -
The Role of Acetylsalicylic Acid as an Assistant Drug in the Management of Hepatocellular Carcinoma
Alacam, Hasan; Bedir, Abdulkerim; Kilinc, Veli; Salis, Osman; Gulten, Sedat (Akad Doktorlar Yayinevi, 2012)Glucose regulated protein 78 (Grp78) is a chaperon which acts in the protein folding. Cell-surface Grp78 is present on the surface of different type cancer cells. There are evidences that acetylsalicylic acid (ASA) provides ...
