Yazar "Goksu, Suleyman" için listeleme
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Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II, and VI
Senturk, Murat; Ekinci, Deniz; Goksu, Suleyman; Supuran, Claudiu T. (Taylor & Francis Ltd, 2012)Studies on carbonic anhydrase (CA, EC 4.2.1.1) inhibitors have increased due to several therapeutic applications while there are few investigations on activators. Here we investigated CA inhibitory and activatory capacities ... -
Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds
Balaydin, Halis Turker; Durdagi, Serdar; Ekinci, Deniz; Senturk, Murat; Goksu, Suleyman; Menzek, Abdullah (Taylor & Francis Ltd, 2012)Carbonic anhydrase inhibitors (CAI) are valuable molecules as they have several therapeutic applications, including anti-glaucoma activity. In this study, inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) ... -
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site
Durdagi, Serdar; Senturk, Murat; Ekinci, Deniz; Balaydin, Halis Turker; Goksu, Suleyman; Kufrevioglu, O. Irfan; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2011)Carbonic anhydrases (CAs, EC 4.2.1.1) are inhibited by sulfonamides, inorganic anions, phenols, coumarins (acting as prodrugs) and polyamines. A novel class of CA inhibitors (CAIs), interacting with the CA isozymes I, II ... -
Synthesis and Biological Evaluation of Novel Bromophenol Derivatives as Carbonic Anhydrase Inhibitors
Akbaba, Yusuf; Balaydin, Halis Turker; Menzek, Abdullah; Goksu, Suleyman; Sahin, Ertan; Ekinci, Deniz (Wiley-V C H Verlag Gmbh, 2013)Here, we provide an alternative synthesis of the natural bromophenol 3,4-dibromo-5-(2,3-dibromo-4,5-dihydroxybenzyl)-6-(ethoxymethyl) benzene-1,2-diol (3) and the first synthesis of (4,5-dihydroxy-2methylphenyl)( ... -
Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural products
Balaydin, Halis Turker; Soyut, Hakan; Ekinci, Deniz; Goksu, Suleyman; Beydemir, Sukru; Menzek, Abdullah; Sahin, Ertan (Taylor & Francis Ltd, 2012)(2-Bromo-3,4-dimethoxyphenyl) (3,4-dimethoxyphenyl) methanone (10) and its derivatives with Br, one dibromide and isomeric three tribromides, were synthesized. Demethylation of these compounds afforded a series of new ...
