Yazar "Durdagi, Serdar" için listeleme
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Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives
Fidan, Ismail; Salmas, Ramin Ekhteiari; Arslan, Mehmet; Senturk, Murat; Durdagi, Serdar; Ekinci, Deniz; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2015)The inhibition of two human cytosolic carbonic anhydrase isozymes I and II, with some novel glycine and phenylalanine sulfonamide derivatives were investigated. Newly synthesized compounds G1-4 and P1-4 showed effective ... -
Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors
Cakmak, Resit; Durdagi, Serdar; Ekinci, Deniz; Senturk, Murat; Topal, Giray (Pergamon-Elsevier Science Ltd, 2011)Discovery of GR inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, the synthesis and GR inhibitory capacities of novel nitroaromatic compounds (NCs) (1-3) were reported. ... -
Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies
Cavdar, Huseyin; Senturk, Murat; Guney, Murat; Durdagi, Serdar; Kayik, Gulru; Supuran, Claudiu T.; Ekinci, Deniz (Taylor & Francis Ltd, 2019)Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) inhibitors are interesting compounds for different therapeutic applications, among which Alzheimer's disease. Here, we investigated the inhibition of these ... -
Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds
Balaydin, Halis Turker; Durdagi, Serdar; Ekinci, Deniz; Senturk, Murat; Goksu, Suleyman; Menzek, Abdullah (Taylor & Francis Ltd, 2012)Carbonic anhydrase inhibitors (CAI) are valuable molecules as they have several therapeutic applications, including anti-glaucoma activity. In this study, inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) ... -
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives
Isik, Semra; Vullo, Daniela; Durdagi, Serdar; Ekinci, Deniz; Senturk, Murat; Cetin, Ahmet; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2015)A series of hydrazinecarbothioamide derivatives incorporating ethyl, phenyl, tolyl, benzyl, and allyl moieties were prepared and tested as possible inhibitors of three members of the pH regulatory enzyme family, carbonic ... -
Kinetic and docking studies of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with some hydroxylic compounds
Durdagi, Serdar; Korkmaz, Neslihan; Isik, Semra; Vullo, Daniela; Astley, Demet; Ekinci, Deniz; Supuran, Claudiu T. (Taylor & Francis Ltd, 2016)A series of hydroxylic compounds (1-10, NK-154 and NK-168) have been assayed for the inhibition of three physiologically relevant carbonic anhydrase isozymes, the cytosolic isozymes I, II and tumor-associated isozyme IX. ... -
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site
Durdagi, Serdar; Senturk, Murat; Ekinci, Deniz; Balaydin, Halis Turker; Goksu, Suleyman; Kufrevioglu, O. Irfan; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2011)Carbonic anhydrases (CAs, EC 4.2.1.1) are inhibited by sulfonamides, inorganic anions, phenols, coumarins (acting as prodrugs) and polyamines. A novel class of CA inhibitors (CAIs), interacting with the CA isozymes I, II ... -
Kinetic and in silico analysis of thiazolidin-based inhibitors of alpha-carbonic anhydrase isoenzymes
Ekinci, Deniz; Fidan, Ismail; Durdagi, Serdar; Kaban, Seniz; Supuran, Claudiu T. (Taylor & Francis Ltd, 2013)Carbonic anhydrases (CAs, EC 4.2.1.1) are inhibited by sulfonamides, inorganic anions, phenols, salicylic acid derivatives (acting as drug or prodrugs). A novel class of CA inhibitors (CAIs), interacting with the CA isozymes ... -
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b] indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI
Ekinci, Deniz; Cavdar, Huseyin; Durdagi, Serdar; Talaz, Oktay; Senturk, Murat; Supuran, Claudiu T. (Elsevier France-Editions Scientifiques Medicales Elsevier, 2012)Several 5,10-dihydroindeno[1,2-b]indole derivatives incorporating methoxy, hydroxyl, and halogen (F, Cl, and Br) moieties on the indene fragment of the molecule were prepared and tested against five carbonic anhydrase (CA, ... -
Synthesis of 1,4-bis(indolin-1-ylmethyl)benzene derivatives and their structure-activity relationships for the interaction of human carbonic anhydrase isoforms I and II
Talaz, Oktay; Cavdar, Huseyin; Durdagi, Serdar; Azak, Hacer; Ekinci, Deniz (Pergamon-Elsevier Science Ltd, 2013)Several 1,4-bis(indolin-1-ylmethyl)benzene-based compounds containing substituents such as five, six and seven cyclic derivatives on indeno part (9a-c) were prepared and tested against two members of the pH regulatory ...
