Yazar "Bedir, Abdulkerim" için listeleme
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The anticancer effects of desferrioxamine on human breast adenocarcinoma and hepatocellular carcinoma cells
Salis, Osman; Bedir, Abdulkerim; Kilinc, Veli; Alacam, Hasan; Gulten, Sedat; Okuyucu, Ali (Ios Press, 2014)N-myc downstream-regulated gene 1 (NDRG1) is defined as metastasis suppressor and can be downregulated in many types of cancers, and reported to be an indication of tumor progression in hepatocellular carcinomas. Several ... -
Antimetastatic effect of fluvastatin on breast and hepatocellular carcinoma cells in relation to SGK1 and NDRG1 genes
Salis, Osman; Okuyucu, Ali; Bedir, Abdulkerim; Gor, Ufuk; Kulcu, Canan; Yenen, Eser; Kilic, Nermin (Sage Publications Ltd, 2016)Metastasis occurs due to migration of the cells from primary tumor toward other tissues by gaining invasive properties. Since metastatic invasion shows a strong resistance against conventional cancer treatments, the studies ... -
Assessment of different folic acid supplementation doses for low-birth-weight infants
Celik, Fatma Cakmak; Aygun, Canan; Gulten, Sedat; Bedir, Abdulkerim; Cetinoglu, Erhan; Kucukdoduk, Sukru; Bek, Yuksel (Turkish Pediatrics Assoc, 2016)Aim: The adequacy of 50 mcg folic acid supplementation given to low-birth-weight babies was investigated. The folate levels of the mothers and infants, and breastmilk, and the optimum dose for folic acid supplementation ... -
Assessment of genotoxicity in rats treated with the antidiabetic agent, pioglitazone
Bedir, Abdulkerim; Aliyazicioglu, Yuksel; Bilgici, Birsen; Yurclakul, Zafer; Uysal, Mehmet; Suvaci, Duygu Erol; Alvur, Muhlise (Wiley, 2008)Pioglitazone (PIO), a member of the thiazolidinedione class of antidiabetic agents, specifically targets insulin resistance. Drugs of this class act as ligands for the gamma subtype of the peroxisome proliferator-activated ... -
Association between adiponectin, resistin, insulin resistance, and colorectal tumors
Gonullu, Guzin; Kahraman, Hakki; Bedir, Abdulkerim; Bektas, Ahmet; Yucel, Idris (Springer, 2010)In this study, we have examined the correlation between colorectal cancer (CRC) and serum adiponectin and resistin levels, body mass index and insulin resistance. The relation between serum adiponectin and resistin levels, ... -
Clinical significance of glucocorticoid receptor expression in premature infants with respiratory distress syndrome
Ataseven, Fevzi; Salis, Osman; Aygun, Canan; Bedir, Abdulkerim; Kucukoduk, Sukru (Taylor & Francis Ltd, 2017)Objective: Previous studies have shown the relationship between lung development and glucocorticoids, but no studies have been conducted to investigate if a relationship exists between respiratory distress syndrome (RDS) ... -
Comparison of predictive powers of S100B and cell-free plasma DNA values in intensive care unit patients with intracranial hemorrhage
Dilek, Ahmet; Alacam, Hasan; Ulger, Fatma; Bedir, Abdulkerim; Ulus, Aykan; Murat, Naci; Polat, Ferdi (W B Saunders Co-Elsevier Inc, 2013)Purpose: To investigate predictive powers of S100B and cell-free DNA (cfDNA) levels in patients in the intensive care unit (ICU) who have with intracranial hemorrhage (ICH) for prognosis. Methods: Ninety-nine patients ... -
Cytotoxic Effect of Fluvastatin on MCF-7 Cells Possibly Through a Reduction of the mRNA Expression Levels of SGK1 and CAV1
Salis, Osman; Bedir, Abdulkerim; Gulten, Sedat; Okuyucu, Ali; Kulcu, Canan; Alacam, Hasan (Mary Ann Liebert, Inc, 2014)Fluvastatin (FLU) prevents the conversion of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonic acid by inhibiting HMG-CoA reductase and decreases cholesterol level. Although the effects of FLU treatment on several ... -
Do iron chelators increase the antiproliferative effect of trichostatin A through a glucose-regulated protein 78 mediated mechanism?
Kilinc, Veli; Bedir, Abdulkerim; Okuyucu, Ali; Salis, Osman; Alacam, Hasan; Gulten, Sedat (Sage Publications Ltd, 2014)Histone deacetylase (HDAC) inhibitors, such as trichostatin A (TSA), and iron chelators, including deferoxamine (DFO) and phenanthroline (PHEN), appear to have anticancer effects. We hypothesized that the HDAC inhibitors ... -
Effect of creatine and pioglitazone on Hk-2 cell line cisplatin nephrotoxicity
Genc, Gurkan; Kilinc, Veli; Bedir, Abdulkerim; Ozkaya, Ozan (Taylor & Francis Ltd, 2014)Cisplatin is a chemotherapeutic agent, which is used in the treatment of various solid organ cancers, and its main dose limiting side effect of cisplatin is nephrotoxicity. The aim of this study is to investigate the role ... -
Effect of dexamethasone on unfolded protein response genes (MTJ1, Grp78, Grp94, CHOP, HMOX-1) in HEp2 cell line
Duzgun, Aynur; Bedir, Abdulkerim; Ozdemir, Tulay; Nar, Rukiye; Kilinc, Veli; Salis, Osman; Gulten, Sedat (Natl Inst Science Communication-Niscair, 2013)The endoplasmic reticulum (ER) is related to the various signal routes that are activated in unfolded protein response (UPR). The Grp78, Grp94, CHOP, MTJ1 and HMOX1 genes expressions demonstrate UPR activity. In this study, ... -
The effect of ouabain on mitochondrial DNA damage in HepG2 cell lines
Nar, Rukiye; Bedir, Abdulkerim; Alacam, Hasan; Kilinc, Veli; Avci, Bahattin; Salis, Osman; Gulten, Sedat (Springer, 2012)Our purpose in this study is to analyze mitochondrial DNA (mtDNA) lesion frequencies and mtDNA(4977) deletion in HepG2 cells to examine the effects of ouabain on mtDNA. HepG2 cells were treated with 0.75, 7.5, 75, and 750 ... -
Effects of circulating endothelial progenitor cells, serum vascular endothelial growth factor and hypogammaglobulinemia in Perthes disease
Sezgin, Hicabi; Gulman, Birol; Cirakli, Alper; Bedir, Abdulkerim; Usta, Dilek; Coskun, Sina; Yildiran, Alisan (Turkish Assoc Orthopaedics Traumatology, 2014)Objective: The aim of this study was to investigate Legg-Calve-Perthes disease (PD) pathogenesis by comparing absolute circulating endothelial progenitor cell (EPC) counts, serum levels of vascular endothelial growth ... -
The Evaluation of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein Levels in Patients with Acute Attack of COPD
Duran, Latif; Unsal, Meftun; Yardan, Turker; Kati, Celal; Bedir, Abdulkerim; Turkeli, Suna; Ekiz, Mehmet (Clin Lab Publ, 2015)Background: Acute exacerbations of chronic obstructive pulmonary disease (COPD) are characterized by the release of inflammatory mediators. The aim of this study was to compare serum levels of pentraxin 3 (PTX3) and ... -
Genotoxicity in rats treated with the antidiabetic agent, rosiglitazone
Bedir, Abdulkerim; Aliyazicioglu, Yuksel; Kahraman, Hakki; Yurdakul, Zafer; Uysal, Mehmet; Suvaci, Duygu Erol; Alvur, Muhlise (Wiley, 2006)Rosiglitazone (RSG), a member of the thiazolidinedione class of antidiabetic agents, improves glycemic control by increasing insulin sensitivity. The therapeutic mode of action of RSG involves its activity as a highly ... -
Glucocorticoid Receptor-beta Is Downregulated by Vitamin D Treatment in Children with Low Vitamin D Levels but Not in Allergic Asthma
Guner, Sukru Nail; Sancak, Recep; Gulten, Sedat; Ozen, Ahmet; Kilic, Mehtap; Bedir, Abdulkerim (Mary Ann Liebert, Inc, 2015)Background: Vitamin D (VitD) enhances the anti-inflammatory effects of glucocorticoids (GC) in vitro. It was hypothesized that VitD3 (colecalciferol) treatment could have an impact on the expression of glucocorticoid ... -
Helicobacter Pylori Eradication Increases Telomere Length in Gastric Mucosa
Aslan, Rahmi; Bektas, Ahmet; Bedir, Abdulkerim; Alacam, Hasan; Aslan, Melek Suzer; Nar, Rukiye; Okuyucu, Ali (H G E Update Medical Publishing S A, 2013)Background/Aims: Our purpose in this study was to analyze telomere length and telomerase activity before and after eradication treatment in gastric mucosa in patients positive for H. pylori. Methodology: There were two ... -
Increased DNA oxidation (8-0HdG) and protein oxidation (AOPP) by low level electromagnetic field (2.45 GHz) in rat brain and protective effect of garlic
Gurler, Hatice S.; Bilgici, Birsen; Akar, Aysegul K.; Tomak, Leman; Bedir, Abdulkerim (Taylor & Francis Ltd, 2014)Purpose: To investigate the oxidative damage and protective effect of garlic on rats exposed to low level of electromagnetic fields (EMF) at 2.45 GHz Microwave radiation (MWR). Methods: Thirty-six Wistar rats were divided ... -
Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia
Erdemli, Haci Kemal; Yildirimlar, Pinar; Alper, Tayfun Yasar; Kocabas, Ramazan; Salis, Osman; Bedir, Abdulkerim (Taylor & Francis Inc, 2014)Objective: To evaluate the utility of serum biomarkers in the diagnosis of preeclampsia (PE) and also investigate possible correlation with pathogenesis of PE. Methods: Maternal serum concentrations of heme oxygenase-1 ... -
Investigation of Genotoxicity in Intestinal Epithelial Cells and Lymphocytes of Celiac Patients
Yuce, Ozlem; Kalayci, Ayhan Gazi; Okuyucu, Ali; Caltepe, Gonul; Bedir, Abdulkerim (Nobel Ilac, 2015)Objective: To investigate the presence of genotoxicity in intestinal epithelial cells and lymphocytes in celiac patients and to assess DNA repair capacity. Material and Method: The study comprised 15 newly diagnosed celiac ...
