Yazar "Bagirici, F" için listeleme
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A calcium channel blocker flunarizine attenuates the neurotoxic effects of iron
Bostanci, MO; Bagirici, F; Canan, S (Springer, 2006)Iron is a metal highly concentrated in liver and brain tissue, and known to induce neuronal hyperactivity and oxidative stress. It has been established that iron levels rise in the brain in some neurodegenerative diseases ... -
Calcium channel blocker flunarizine suppresses epileptiform activity induced by penicillin in rats
Bagirici, F; Gokce, FM; Demir, S; Marangoz, C (John Wiley & Sons Inc, 2001)Epilepsy is a neurological disorder that affects approximately 1% of the world population. It is accepted that calcium influx into the cell is the first step of epileptic neuronal events. In the present study, the effects ... -
A calcium channel blocker nicardipine protects neurons from zinc - Induced toxicity in rat hippocampus
Demir, S; Bagirici, F; Marangoz, C (John Wiley & Sons Ltd, 2002)The neurotoxicity is an important problem in medicine. The present study was designed to investigate the changes in pyramidal cell density of rat hippocampus after intracortical zinc sulphate (ZnSO4) and calcium channel ... -
Depressive effect of nicardipine on penicillin-induced epileptiform activity in rats
Bagirici, F; Gokce, FM; Marangoz, C (John Wiley & Sons Ltd, 1999)It is believed that calcium ions have very important role in the formation of epilepsy. Calcium ion flux into the cell leads to secretion of excitatory neurotransmitters. During epileptic seizures, routine balance of ... -
Effects of flunarizine on cadmium-induced Purkinje cell loss in rats
Genc, H; Bagirici, F; Cakir, A; Demir, S; Tan, F (John Wiley & Sons Ltd, 2001)The effects of the calcium channel blocker flunarizine on cadmium-induced Purkinje cell loss in the cerebellum of rats were investigated. Rats were divided into three groups: control, cadmium, and cadmium+flunarizine. ... -
Effects of L-arginine on penicillin-induced epileptiform activity in rats
Marangoz, C; Bagirici, F (Japanese Pharmacological Soc, 2001)It has been suggested that nitric oxide (NO) is involved in the pathophysiology of epilepsy. Data are, however controversial because it is not clear whether NO has pro- or anticonvulsant effects. The aim of this study was ... -
Neuroprotective effect of nicardipine on cadmium-induced Purkinje cell death in rat, cerebellum
Bagirici, F; Genc, H; Tan, F; Demir, S (John Wiley & Sons Ltd, 2001)The present study was designed to investigate the effects of nicardipine on cadmium-induced Purkinje cell loss in cerebellum of rats. Animals were divided into three groups as control, cadmium and cadmium + nicardipine ... -
The neurotoxic effect of iron on pyramidal cell number in rat hippocampus: A stereological study
Bostanci, MO; Bagirici, F; Korkmaz, A (Wiley, 2003)There have been numerous studies of neuronal hyperactivity and oxidative stress induced by iron. Moreover, it has been found that iron levels in the brain are markedly increased in some neurodegenerative diseases such as ... -
A NOS inhibitor aminoguanidine reduces zinc-induced neuron loss in rat hippocampus
Gokce, FM; Bagirici, F; Kaplan, S; Demir, S; Ayyildiz, M; Marangoz, C (John Wiley & Sons Ltd, 2003)There are many studies on zinc as a possible cause of neuronal hyperactivity and cell death. The present study was designed to investigate the changes in total pyramidal cell number of rat hippocampus after intracortical ... -
Proconvulsant effects of central and peripheral administration of L-name on penicillin-induced epilepsy in rats
Bagirici, F; Marangoz, C (John Wiley & Sons Ltd, 2001)The effect of Nm-nitro L-arginine methyl ester (L-NAME) on penicillin-induced epileptiform activity was investigated in anaesthetized Wistar rats. Approximately 39.1 +/- 5.7 min after penicillin G (3 million U/kg, i.p.) ... -
The role of L-type calcium channels in spinal reflex responses in cats
Tasci, N; Genc, O; Bagirici, F (John Wiley & Sons Ltd, 2003)We have investigated the effects of verapamil, which blocks L-type calcium channels on spinal monosynaptic reflexes in spinalized cats. Adult cats (n=10) weighing 1.5-3 kg were anaesthetized with ketamine (50 mg/kg, IM) ...
