Yazar "Alacam, Hasan" için listeleme
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Analysis of the Protective Biochemical and Pathologic Effects of Aminoguanidine on an Experimental Aspiration Pneumonitis Model Induced by Bile Acids
Karli, Rifat; Alacam, Hasan; Duran, Latif; Alici, Omer; Kati, Celal; Karli, Arzu; Guzel, Ahmet (Elsevier Science Inc, 2012)BACKGROUND: Gastroesophageal reflux (GER) is a common clinical pathology detected in childhood. Bile acids (BAs) are present in reflux and cause various pathologies in the esophagus, the larynx, and the lungs. OBJECTIVE: ... -
The anticancer effects of desferrioxamine on human breast adenocarcinoma and hepatocellular carcinoma cells
Salis, Osman; Bedir, Abdulkerim; Kilinc, Veli; Alacam, Hasan; Gulten, Sedat; Okuyucu, Ali (Ios Press, 2014)N-myc downstream-regulated gene 1 (NDRG1) is defined as metastasis suppressor and can be downregulated in many types of cancers, and reported to be an indication of tumor progression in hepatocellular carcinomas. Several ... -
Apoptosis-Related Gene Expression in an Adult Cohort with Crimean-Congo Hemorrhagic Fever
Guler, Nil; Eroglu, Cafer; Yilmaz, Hava; Karadag, Adil; Alacam, Hasan; Sunbul, Mustafa; Leblebicioglu, Hakan (Public Library Science, 2016)Crimean-Congo Hemorrhagic Fever (CCHF) is a life threatening acute viral infection characterized by fever, bleeding, leukopenia and thrombocytopenia. It is a major emerging infectious diseases threat, but its pathogenesis ... -
Comparison of predictive powers of S100B and cell-free plasma DNA values in intensive care unit patients with intracranial hemorrhage
Dilek, Ahmet; Alacam, Hasan; Ulger, Fatma; Bedir, Abdulkerim; Ulus, Aykan; Murat, Naci; Polat, Ferdi (W B Saunders Co-Elsevier Inc, 2013)Purpose: To investigate predictive powers of S100B and cell-free DNA (cfDNA) levels in patients in the intensive care unit (ICU) who have with intracranial hemorrhage (ICH) for prognosis. Methods: Ninety-nine patients ... -
Cytotoxic Effect of Fluvastatin on MCF-7 Cells Possibly Through a Reduction of the mRNA Expression Levels of SGK1 and CAV1
Salis, Osman; Bedir, Abdulkerim; Gulten, Sedat; Okuyucu, Ali; Kulcu, Canan; Alacam, Hasan (Mary Ann Liebert, Inc, 2014)Fluvastatin (FLU) prevents the conversion of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonic acid by inhibiting HMG-CoA reductase and decreases cholesterol level. Although the effects of FLU treatment on several ... -
Do iron chelators increase the antiproliferative effect of trichostatin A through a glucose-regulated protein 78 mediated mechanism?
Kilinc, Veli; Bedir, Abdulkerim; Okuyucu, Ali; Salis, Osman; Alacam, Hasan; Gulten, Sedat (Sage Publications Ltd, 2014)Histone deacetylase (HDAC) inhibitors, such as trichostatin A (TSA), and iron chelators, including deferoxamine (DFO) and phenanthroline (PHEN), appear to have anticancer effects. We hypothesized that the HDAC inhibitors ... -
Does ADMA affect the oxidant/antioxidant balance in rats?
Alacam, Hasan; Avci, Bahattin; Salis, Osman; Dilek, Ahmet; Kozan, Ahmet; Mertoglu, Cuma; Okuyucu, Ali (Tubitak Scientific & Technical Research Council Turkey, 2013)Aim: Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide synthase (NOS). Oxidative stress might be defined as an imbalance between protein oxidation and antioxidants. Our aim was to determine in vivo whether ... -
The effect of curcumin on lung injuries in a rat model induced by aspirating gastrointestinal decontamination agents
Gunaydin, Mithat; Guzel, Aygul; Guzel, Ahmet; Alacam, Hasan; Salis, Osman; Murat, Naci; Guvenc, Tolga (W B Saunders Co-Elsevier Inc, 2012)Background: Aspiration is one of the most feared complications of gastrointestinal decontamination procedures with nonabsorbed polyethylene glycol (PEG) solution and activated charcoal (AC). We aimed to investigate the ... -
Effect of infliximab on acute hepatic ischemia/reperfusion injury in rats
Yucel, Ahmet Fikret; Pergel, Ahmet; Aydin, Ibrahim; Alacam, Hasan; Karabicak, Ilhan; Kesicioglu, Tugrul; Sahin, Dursun Ali (E-Century Publishing Corp, 2015)This study aimed to investigate the hepatoprotective and antioxidant effects of infliximab (IFX) against liver ischemia/reperfusion (I/R) injury in rats. A total of 30 male Wistar albino rats were divided into three groups: ... -
Effect of methylphenidate treatment on appetite and levels of leptin, ghrelin, adiponectin, and brain-derived neurotrophic factor in children and adolescents with attention deficit and hyperactivity disorder
Sahin, Serkan; Yuce, Murat; Alacam, Hasan; Karabekiroglu, Koray; Say, Gokce Nur; Salis, Osman (Taylor & Francis Ltd, 2014)Objectives. We aimed to explore whether the use of methylphenidate relates leptin, ghrelin, adiponectin, and brain-derived neurotrophic factor (BDNF). In addition, the relationship between methylphenidate-related weight ... -
The effect of ouabain on mitochondrial DNA damage in HepG2 cell lines
Nar, Rukiye; Bedir, Abdulkerim; Alacam, Hasan; Kilinc, Veli; Avci, Bahattin; Salis, Osman; Gulten, Sedat (Springer, 2012)Our purpose in this study is to analyze mitochondrial DNA (mtDNA) lesion frequencies and mtDNA(4977) deletion in HepG2 cells to examine the effects of ouabain on mtDNA. HepG2 cells were treated with 0.75, 7.5, 75, and 750 ... -
The Effectiveness of the Serum Surfactant Protein D (Sp-D) Level to Indicate Lung Injury in Pulmonary Embolism
Kati, Celal; Alacam, Hasan; Duran, Latif; Guzel, Aygul; Akdemir, Hizir Ufuk; Sisman, Bulent; Okuyucu, Ali (Clin Lab Publ, 2014)Background: Surfactant protein D (SP-D) is a biomarker specific to the lungs. Our aim was to investigate the relationship between clinical probability scores and the serum levels of SP-D to indicate the severity of lung ... -
Effects of asymmetric dimethylarginine on inflammatory cytokines (TNF-alpha, IL-6 and IL-10) in rats
Avci, Bahattin; Alacam, Hasan; Dilek, Ahmet; Kozan, Ahmet (Sage Publications Inc, 2015)This study is intended to examine the effects of administration of asymmetric dimethylarginine (ADMA) on the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-10. A total of 30 Wistar adult ... -
The Effects of Dexamethasone and L-NAME on Acute Lung Injury in Rats with Lung Contusion
Kozan, Ahmet; Kilic, Nermin; Alacam, Hasan; Guzel, Ahmet; Guvenc, Tolga; Acikgoz, Mehmet (Springer/Plenum Publishers, 2016)The therapeutic efficiency of an anti-inflammatory agent, dexamethasone (DXM), and a nitric oxide synthase (NOS) inhibitor, Nitro-L-arginine methyl ester (L-NAME), in lung tissue injury after lung contusion was investigated. ... -
The Effects of Noise on Oxidative and Antioxidative Balance in Human Erythrocytes
Pinar, Tevfik; Atli, A. Kadir; Alacam, Hasan; Karabulut, Ismail; Soguksulu, Ismail; Atas, Ahmet; Akyol, Omer (Akad Doktorlar Yayinevi, 2011)Reactive oxygen and nitrogen species have been implicated in the pathogenesis of noise-induced hearing loss. In this case-control study, we investigated the oxidative and antioxidative status of erythrocytes from workers ... -
The evaluation of different treatment protocols for trauma-induced lung injury in rats
Akdemir, Hizir Ufuk; Guzel, Aygul; Kati, Celal; Duran, Latif; Alacam, Hasan; Gacar, Ayhan; Sisman, Bulent (Ame Publ Co, 2014)Background: Lung contusion is an important factor that affects mortality and morbidity of lung injury after blunt chest trauma (BCT). The present study aims to evaluate the effectiveness of different treatment regimens on ... -
Evaluation of serum endothelial cell specific molecule-1 (endocan) levels as a biomarker in patients with pulmonary thromboembolism
Guzel, Aygul; Duran, Latif; Koksal, Nurhan; Torun, Aysun Caglar; Alacam, Hasan; Ekiz, Birsen Cirit; Murat, Naci (Lippincott Williams & Wilkins, 2014)The aim of this study was to investigate the relationship between pulmonary thromboembolism (PTE) and serum endocan levels. The study included 46 patients with a diagnosis of PTE and control group (25 healthy individuals). ... -
The Evaluation of Serum Surfactant Protein D (SP-D) Levels as a Biomarker of Lung Injury in Tuberculosis and Different Lung Diseases
Guzel, Aygul; Karadag, Adil; Okuyucu, Ali; Alacam, Hasan; Kucuk, Yasemin (Clin Lab Publ, 2014)Background: To evaluate the predictive powers of serum surfactant protein D (SP-D) levels as a biomarker of lung damage in tuberculosis and lung diseases. Methods: This study prospectively included 137 subjects who applied ... -
Helicobacter Pylori Eradication Increases Telomere Length in Gastric Mucosa
Aslan, Rahmi; Bektas, Ahmet; Bedir, Abdulkerim; Alacam, Hasan; Aslan, Melek Suzer; Nar, Rukiye; Okuyucu, Ali (H G E Update Medical Publishing S A, 2013)Background/Aims: Our purpose in this study was to analyze telomere length and telomerase activity before and after eradication treatment in gastric mucosa in patients positive for H. pylori. Methodology: There were two ... -
Infliximab attenuates activated charcoal and polyethylene glycol aspiration-induced lung injury in rats
Guzel, Aygul; Gunaydin, Mithat; Guzel, Ahmet; Alacam, Hasan; Murat, Naci; Gacar, Ayhan; Guvenc, Tolga (Taylor & Francis Inc, 2012)Aspiration is a serious complication of gastrointestinal (GI) decontamination procedure. Studies have shown that tumor necrosis factor-alpha (TNF-alpha) blockers have beneficial effects on lung injury. Therefore, the authors ...
