Interictal Epileptiform Discharges on Electroencephalography in Children with Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms

Abstract

Objective Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism. MTHFR C677T and A1298C polymorphisms are best-defined variants of MTHFR that were reported to be associated with epilepsy development. The aim of the study was to determine the incidence of interictal epileptiform discharges on electroencephalography (EEG) in asymptomatic children with C677T and A1298C polymorphisms who had no history of seizure. Methods Children with MTHFR C677T or A1298C polymorphisms who had normal neurological examination without a history of seizure were included in the study. Blood samples for serum folate, vitamin B12, and homocysteine levels were analyzed. Sleep and awake electroencephalograms (EEG) were recorded. Results A total of 102 children (50 girls and 52 boys) with a mean age of 59.4 +/- 58.7 months were included in the study. Interictal epileptiform EEG discharges were detected in 3 children (2.9%). Conclusion There was no increase in the prevalence of interictal epileptiform discharges in seizure-free and asymptomatic children with MTHFR C677T and A1298C polymorphisms.