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New Palladium(II) and Platinum(II) 5,5-Diethylbarbiturate Complexes with 2-Phenylpyridine, 2,2′-Bipyridine and 2,2′-Dipyridylamine: Synthesis, Structures, DNA Binding, Molecular Docking, Cellular Uptake, Antioxidant Activity and Cytotoxicity

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dc.authorscopusid55551960400
dc.authorscopusid58717985000
dc.authorscopusid35181446100
dc.authorscopusid6507670789
dc.authorscopusid15033124400
dc.authorscopusid36039473500
dc.contributor.authorIcsel, C.
dc.contributor.authorYilmaz, V.T.
dc.contributor.authorKaya, Y.
dc.contributor.authorŞamli, H.
dc.contributor.authorHarrison, W.T.A.
dc.contributor.authorBüyuk̈güngör, O.
dc.date.accessioned2020-06-21T13:51:59Z
dc.date.available2020-06-21T13:51:59Z
dc.date.issued2015
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Icsel] Ceyda, Department of Chemistry, Bursa Uludağ Üniversitesi, Bursa, Bursa, Turkey; [Yilmaz] Veysel T., Department of Chemistry, Bursa Uludağ Üniversitesi, Bursa, Bursa, Turkey; [Kaya] Yunus, Department of Chemistry, Bursa Uludağ Üniversitesi, Bursa, Bursa, Turkey; [Şamli] Hale, Department of Genetics, Bursa Uludağ Üniversitesi, Bursa, Bursa, Turkey; [Harrison] William T.A., Department of Chemistry, University of Aberdeen, Aberdeen, Scotland, United Kingdom; [Büyuk̈güngör] Orhan, Department of Physics, Ondokuz Mayis University Faculty of Science and Arts, Samsun, Turkeyen_US
dc.description.abstractNovel palladium(ii) and platinum(ii) complexes of 5,5-diethylbarbiturate (barb) with 2-phenylpyridine (Hppy), 2,2′-bipyridine (bpy) and 2,2′-dipyridylamine (dpya) have been prepared and characterized by elemental analysis, IR, UV-Vis, NMR and ESI-MS. Single-crystal diffraction measurements show that complex 1 consists of binuclear [Pd<inf>2</inf>(μ-barb-κN,O)<inf>2</inf>(ppy-κN,C)<inf>2</inf>] moieties, while complexes 3-5 are mononuclear, [M(barb-κN)<inf>2</inf>(L-κN,N′)] (L = bpy or dpya). 6 has a composition of [Pt(dpya-κN,N′)<inf>2</inf>][Ag(barb-κN)<inf>2</inf>]<inf>2</inf>·4H<inf>2</inf>O and 2 was assumed to have a structure of [Pt(barb-κN)(Hppy-κN)(ppy-κN,C)]·3H<inf>2</inf>O. The complexes were found to exhibit significant DNA binding affinity by a non-covalent binding mode, in accordance with molecular docking studies. In addition, complexes 1 and 2 displayed strong binding with supercoiled pUC19 plasmid DNA. Cellular uptake studies were performed to assess the subcellular localization of the selected complexes. A moderate radical scavenging activity of 1 and 2 was confirmed by DPPH and ABTS tests. Complexes 1, 2, and 5 showed selectivity against HT-29 (colon) cell line. © The Royal Society of Chemistry.2015.en_US
dc.identifier.doi10.1039/c5dt00728c
dc.identifier.endpage6895en_US
dc.identifier.issn1477-9226
dc.identifier.issn1477-9234
dc.identifier.issue15en_US
dc.identifier.pmid25771855
dc.identifier.scopus2-s2.0-84926433538
dc.identifier.scopusqualityQ2
dc.identifier.startpage6880en_US
dc.identifier.urihttps://doi.org/10.1039/c5dt00728c
dc.identifier.urihttps://hdl.handle.net/20.500.12712/14800
dc.identifier.volume44en_US
dc.identifier.wosWOS:000352271900022
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofDalton Transactionsen_US
dc.relation.journalDalton Transactionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleNew Palladium(II) and Platinum(II) 5,5-Diethylbarbiturate Complexes with 2-Phenylpyridine, 2,2′-Bipyridine and 2,2′-Dipyridylamine: Synthesis, Structures, DNA Binding, Molecular Docking, Cellular Uptake, Antioxidant Activity and Cytotoxicityen_US
dc.typeArticleen_US
dspace.entity.typePublication

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