Publication:
Synthesis and Antidepressant-Like Profile of Novel 1-Aryl Piperidine-1 Derivatives

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dc.authorscopusid7003772860
dc.authorscopusid6701590971
dc.contributor.authorKöksal, M.
dc.contributor.authorBilge, S.
dc.date.accessioned2020-06-21T15:19:56Z
dc.date.available2020-06-21T15:19:56Z
dc.date.issued2007
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Köksal] Meriç, Department of Pharmeceutical Chemistry, Yeditepe University, Istanbul, Turkey, Department of Pharmaceutical Chemistry, Yeditepe University, Istanbul, Turkey; [Bilge] Süleyman Sirri, Department of Pharmacology, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractThis study describes the chemical synthesis and pharmacological evaluation of some new 1-aryl-3-[(4-benzyl)piperidine-1-yl]propane derivatives as antidepressants. The structures attributed to the compounds were elucidated using IR and 1H-NMR spectroscopic techniques besides elemental analysis. The antidepressant-like effect of these compounds was assessed by using the forced swimming test (FST), a validated experimental model of depression in mice. A clear antidepressant-like effect was shown for compounds 1, 2 and 4 by a significant decrease in immobility behaviour. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.en_US
dc.identifier.doi10.1002/ardp.200700028
dc.identifier.endpage303en_US
dc.identifier.issn0365-6233
dc.identifier.issn1521-4184
dc.identifier.issue6en_US
dc.identifier.pmid17562562
dc.identifier.scopus2-s2.0-34250899077
dc.identifier.scopusqualityQ1
dc.identifier.startpage299en_US
dc.identifier.urihttps://doi.org/10.1002/ardp.200700028
dc.identifier.volume340en_US
dc.identifier.wosWOS:000247672900003
dc.identifier.wosqualityQ2
dc.language.isoenen_US
dc.publisherWiley-VCH Verlag GmbHen_US
dc.relation.ispartofArchiv Der Pharmazieen_US
dc.relation.journalArchiv Der Pharmazieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntidepressant-Like Effecten_US
dc.subjectAryl Propane Derivativesen_US
dc.subjectForced Swimming Testen_US
dc.subjectSSRI (Selective Serotonin Reuptake Inhibitors)en_US
dc.subjectSubstituted Piperidineen_US
dc.titleSynthesis and Antidepressant-Like Profile of Novel 1-Aryl Piperidine-1 Derivativesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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