N-(3-Oxo-1-Thia-4-Azaspiro[4.5]dec-4-yl)-6-Phenylimidazo[2,1-b][1,3]thiazole3-Acetamide Hemihydrate

Abstract

The title compound, C21H22N4O2S2·0.5H2O, crystallizes with two mol-ecules in the asymmetric unit. The dihedral angles between the phenyl and imidazothiazole ring systems are 19.16 (9) and 21.37 (9)°. In the imidazothiazole ring systems, the cyclohexane rings adopt chair conformations, while the thiazole rings have distorted envelope conformations. The two mol-ecules are stabilized by intra-molecular N - H⋯O, O - H⋯O and C - H⋯S inter-actions and the crystal structure is stabilized by inter-molecular N - H⋯O, O - H⋯O, C - H⋯O and C - H⋯N inter-actions.