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Synthesis, Structural Characterization and Cell Death-Inducing Effect of Novel Palladium(II) and Platinum(II) Saccharinate Complexes with 2-(Hydroxymethyl)pyridine and 2-(2-Hydroxyethyl)pyridine on Cancer Cells in Vitro

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dc.authorscopusid24376085300
dc.authorscopusid55853882900
dc.authorscopusid55551960400
dc.authorscopusid58717985000
dc.authorscopusid25027291500
dc.authorscopusid36039473500
dc.authorscopusid36039473500
dc.contributor.authorAri, F.
dc.contributor.authorAztopal, N.
dc.contributor.authorIcsel, C.
dc.contributor.authorYilmaz, V.T.
dc.contributor.authorGüney, E.
dc.contributor.authorBüyuk̈güngör, O.
dc.contributor.authorUlukaya, E.
dc.date.accessioned2020-06-21T14:04:24Z
dc.date.available2020-06-21T14:04:24Z
dc.date.issued2013
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Ari] Ferda, Department of Biology, Bursa Uludağ Üniversitesi, Bursa, Bursa, Turkey; [Aztopal] Nazlihan, Department of Biology, Bursa Uludağ Üniversitesi, Bursa, Bursa, Turkey; [Icsel] Ceyda, Department of Chemistry, Bursa Uludağ Üniversitesi, Bursa, Bursa, Turkey; [Yilmaz] Veysel T., Department of Chemistry, Bursa Uludağ Üniversitesi, Bursa, Bursa, Turkey; [Güney] Emel, Department of Chemistry, Bursa Uludağ Üniversitesi, Bursa, Bursa, Turkey; [Büyuk̈güngör] Orhan, Department of Physics, Ondokuz Mayis University Faculty of Science and Arts, Samsun, Turkey; [Ulukaya] Engin, Department of Medical Biochemistry, Bursa Uludağ Üniversitesi, Bursa, Bursa, Turkeyen_US
dc.description.abstractFour palladium(II) and platinum(II) saccharinate (sac) complexes with 2-(hydroxymethyl)pyridine (2-hmpy) and 2-(2-hydroxyethyl)pyridine (2-hepy), namely trans-[Pd(2-hmpy)<inf>2</inf>(sac)<inf>2</inf>]·H<inf>2</inf>O (1), trans-[Pt(2-hmpy)<inf>2</inf>(sac)<inf>2</inf>]·3H<inf>2</inf>O (2), trans-[Pd(2-hepy)<inf>2</inf>(sac)<inf>2</inf>] (3) and trans-[Pt(2-hepy) <inf>2</inf>(sac)<inf>2</inf>] (4), have been synthesized and characterized by elemental analysis, UV-vis, IR and NMR. Single crystal X-ray analysis reveals that the metal(II) ions in each complex are coordinated by two sac and two 2-hmpy or 2-hepy ligands with a trans arrangement. Anticancer effects of 1-4 were tested against four different cancer cell lines (A549 and PC3 for lung cancer, C6 for glioblastoma, and Hep3B for liver cancer). Cytotoxicity was first screened by the MTT assay and the results were further confirmed by the ATP assay. The mode of cell death was determined by both histological and biochemical methods. Among the metal complexes, complex 2 resulted in relatively stronger anti-growth effect in a dose-dependent manner (3.13-200 μM), compared to the others, by inducing apoptosis. © 2013 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.bmc.2013.08.050
dc.identifier.endpage6434en_US
dc.identifier.issn0968-0896
dc.identifier.issn1464-3391
dc.identifier.issue21en_US
dc.identifier.pmid24054490
dc.identifier.scopus2-s2.0-84885185932
dc.identifier.scopusqualityQ2
dc.identifier.startpage6427en_US
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2013.08.050
dc.identifier.volume21en_US
dc.identifier.wosWOS:000325164500017
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofBioorganic & Medicinal Chemistryen_US
dc.relation.journalBioorganic & Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCanceren_US
dc.subjectCytotoxicityen_US
dc.subjectPalladium(II) and Platinum(II) Complexesen_US
dc.titleSynthesis, Structural Characterization and Cell Death-Inducing Effect of Novel Palladium(II) and Platinum(II) Saccharinate Complexes with 2-(Hydroxymethyl)pyridine and 2-(2-Hydroxyethyl)pyridine on Cancer Cells in Vitroen_US
dc.typeArticleen_US
dspace.entity.typePublication

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