Publication: Severe Neurological Outcomes After Very Early Bilateral Nephrectomies in Patients With Autosomal Recessive Polycystic Kidney Disease (ARPKD)
| dc.authorscopusid | 57196234704 | |
| dc.authorscopusid | 6602702810 | |
| dc.authorscopusid | 56339294200 | |
| dc.authorscopusid | 35340836700 | |
| dc.authorscopusid | 8655740200 | |
| dc.authorscopusid | 57193547651 | |
| dc.authorscopusid | 12545842800 | |
| dc.contributor.author | Burgmaier, K. | |
| dc.contributor.author | Ariceta, G. | |
| dc.contributor.author | Bald, M. | |
| dc.contributor.author | Büscher, A.K. | |
| dc.contributor.author | Burgmaier, M. | |
| dc.contributor.author | Erger, F. | |
| dc.contributor.author | Gessner, M. | |
| dc.date.accessioned | 2025-12-11T00:27:09Z | |
| dc.date.issued | 2020 | |
| dc.department | Ondokuz Mayıs Üniversitesi | en_US |
| dc.department-temp | [Burgmaier] Kathrin, Department of Pediatrics, Universität zu Köln, Koln, Nordrhein-Westfalen, Germany; [Ariceta] Gema, Department of Nephrology, Hospital Universitari Vall d'Hebron, Barcelona, Barcelona, Spain; [Bald] Martin K., Department of Nephrology, Klinikum Stuttgart, Stuttgart, Baden-Wurttemberg, Germany; [Büscher] Anja Katrin, Department of Pediatrics, Universitätsklinikum Essen, Essen, Nordrhein-Westfalen, Germany; [Burgmaier] Mathias, Department of Internal Medicine, Uniklinik RWTH Aachen, Aachen, Nordrhein-Westfalen, Germany; [Erger] Florian, Institute of Human Genetics, Uniklinik Köln, Koln, Nordrhein-Westfalen, Germany, Medizinische Fakultät, Koln, Nordrhein-Westfalen, Germany; [Gessner] Michaela, Department of General Pediatrics and Hematology/Oncology, Universitätsklinikum und Medizinische Fakultät Tübingen, Tubingen, Baden-Wurttemberg, Germany; [G?k?e] ?brahim, Division of Pediatric Nephrology, Research and Training Hospital, Marmara Üniversitesi, Istanbul, Turkey; [König] Jens Christian, Department of General Pediatrics, Universitätsklinikum Münster, Munster, Niedersachsen, Germany; [Kowalewska] Claudia, Instytut "Pomnik - Centrum Zdrowia Dziecka", Warsaw, MA, Poland; [Massella] Laura, Department of Pediatric Subspecialties, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, RM, Italy; [Mastrangelo] Antonio Pio, Pediatric Nephrology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, MI, Italy; [Mekahli] Djalila, Department of Development and Regeneration, KU Leuven, Leuven, Vlaams-Brabant, Belgium, Department of Pediatric Nephrology, KU Leuven– University Hospital Leuven, Leuven, Vlaams-Brabant, Belgium; [Pape] Lars, Department of Pediatrics, Universitätsklinikum Essen, Essen, Nordrhein-Westfalen, Germany, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Niedersachsen, Germany; [Patzer] Ludwig, Krankenhaus St. Elisabeth und St. Barbara, Halle, Sachsen-Anhalt, Germany; [Potemkina] Alexandra, Medizinische Universität Wien Universitätsklinik für Kinder- und Jugendheilkunde, Vienna, Vienna, Austria; [Schalk] Gesa, Department of Pediatrics, Universitätsklinikum Bonn, Bonn, Nordrhein-Westfalen, Germany; [Schild] Raphael Sebastian, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Hamburg, Germany; [Shroff] Rukshana C., University College London, London, United Kingdom; [Szczepanska] Maria, Department of Pediatrics, Slaski Uniwersytet Medyczny w Katowicach, Katowice, SL, Poland; [Taranta-Janusz] Katarzyna, Department of Paediatrics and Nephrology, Uniwersytet Medyczny w Bialymstoku, Bialystok, PD, Poland; [Tkaczyk] Marcin, Department of Pediatrics, Immunology and Nephrology, Instytut Centrum Zdrowia Matki Polki, Lodz, LD, Poland; [Weber] Lutz Thorsten, Department of Pediatrics, Universität zu Köln, Koln, Nordrhein-Westfalen, Germany; [Wühl] Elke, Division of Pediatric Nephrology, Universitätsklinikum Heidelberg, Heidelberg, Baden-Wurttemberg, Germany; [Wurm] Donald, Department of Pediatrics, Klinikum Saarbrücken, Saarbrucken, Saarland, Germany; [Wygoda] Simone, Clinic for Children and Adolescents, Klinikum St. Georg Leipzig, Leipzig, Sachsen, Germany; [Zagożdżon] Ilona, Department of Pediatric and Adolescent Nephrology and Hypertension, Gdanski Uniwersytet Medyczny, Gdansk, Pomeranian, Poland; [Dötsch] Jörg, Department of Pediatrics, Universität zu Köln, Koln, Nordrhein-Westfalen, Germany; [Oh] Jun, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Hamburg, Germany; [Schaefer] Franz S., Division of Pediatric Nephrology, Universitätsklinikum Heidelberg, Heidelberg, Baden-Wurttemberg, Germany; [Liebau] Max Christoph, Department of Pediatrics, Universität zu Köln, Koln, Nordrhein-Westfalen, Germany, Medizinische Fakultät, Koln, Nordrhein-Westfalen, Germany; [Eid] Loai Akram, Pediatric Nephrology Department, Dubai Hospital, Dubai, United Arab Emirates; [Arbeiter] Klaus M., Medizinische Universität Wien Universitätsklinik für Kinder- und Jugendheilkunde, Vienna, Vienna, Austria; [Ranguelov] Nadejda, Department of Pediatrics, Faculté de Médecine et Médecine Dentaire, Louvain-la-Neuve, WBR, Belgium; [Collard] Laure, Clinique de l’Espérance, Centre de référence de Néphrologie Pédiatrique Sud, Montegnee, Belgium; [De-Mul] Aurelie, Unité Romande de Néphrologie Pédiatrique, Hôpitaux Universitaires de Genève, Geneva, GE, Switzerland; [Feldkoetter] Markus, Nephrology Unit, Kinderspital Zürich, Zurich, Switzerland; [Seeman] Tomáš, Department of Pediatrics, Fakultní Nemocnice v Motole, Prague, Czech Republic; [Thumfart] Julia, Department of Pediatric Nephrology, Berliner Institut für Gesundheitsforschung, Berlin, Berlin, Germany; [Grundmann] Franziska, Department II of Internal Medicine, Uniklinik Köln, Koln, Nordrhein-Westfalen, Germany; [Galiano] Matthias, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Bayern, Germany; [Buchholz] Björn, Department of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Bayern, Germany; [Buescher] Rainer, Department of Pediatrics, Universitätsklinikum Essen, Essen, Nordrhein-Westfalen, Germany; [Häffner] Karsten, Department of Pediatrics and Adolescent Medicine, Universitätsklinikum Freiburg, Freiburg im Breisgau, Baden-Wurttemberg, Germany; [Gross] Oliver, Department of Nephrology and Rheumatology, Universitätsmedizin Göttingen, Gottingen, Niedersachsen, Germany; [Bernhardt] Wanja Michael, Nephrology Clinic Hannover, Hannover, Germany; [Doyon] Anke, Division of Pediatric Nephrology, Universitätsklinikum Heidelberg, Heidelberg, Baden-Wurttemberg, Germany; [Henn] Michael, Clinic for Children and Adolescents, Klinikum St. Georg Leipzig, Leipzig, Sachsen, Germany; [Halbritter] J., Division of Nephrology, Universitätsklinikum Leipzig und Medizinische Fakultät, Leipzig, Sachsen, Germany; [Derichs] Ute, Pediatric Nephrology, Universitätsmedizin Mainz, Mainz, Rheinland-Pfalz, Germany; [Klaus] Günter, KfH Center of Paediatric Nephrology, Universitätsklinikum Gießen und Marburg, Standort Marburg, Marburg, Hessen, Germany; [Lange-Sperandio] Bärbel, Klinikum der Universität München, Munich, Bayern, Germany; [Uetz] Barbara, KfH Center of Pediatric Nephrology, Klinikum Schwabing, Munich, Bayern, Germany; [Benz] Marcus R., Klinikum Dritter Orden, Munich, Bayern, Germany; [Titieni] Andrea, Department of General Pediatrics, Universitätsklinikum Münster, Munster, Niedersachsen, Germany; [Staude] Hagen, Pediatric Nephrology, Universität Rostock Uniklinikum und Medizinische Fakultät, Rostock, Mecklenburg-Vorpommern, Germany; [Leichter] Heinz E., Clinic of Stuttgart, Olga Children's Hospital, Stuttgart, Germany; [Soliman Elshakhs] Neveen A., Center of Pediatric Nephrology and Transplantation, Faculty of Medicine, Cairo, Cairo, Egypt; [Lara] Luis Enrique, Department of Nephrology, Hospital Universitari Vall d'Hebron, Barcelona, Barcelona, Spain; [de la Cerda-Ojeda] Francisco, Hospital Universitario Virgen del Rocío, Sevilla, Seville, Spain; [Harambat] Jérǒme, Department of Pediatrics, Centre Hospitalier Universitaire de Bordeaux, Talence, Nouvelle-Aquitaine, France; [Ranchin] Bruno, CHU de Lyon, Lyon, Auvergne-Rhone-Alpes, France; [Fila] Marc, Pediatric Nephrology Unit, Hopital Arnaud de Villeneuve, Montpellier, Occitanie, France; [Dossier] Claire, Service de Néphrologie Pédiatrique, Hôpital Robert-Debré AP-HP, Paris, France; [Boyer] Olivia Gillion, Department of Nephrology and Kidney Transplantation, Hôpital Necker Enfants Malades, Paris, France; [Marlais] Matko, University College London, London, United Kingdom; [Stabouli] Stella V., Department of Pediatrics, Aristotle University of Thessaloniki, Thessaloniki, Central Macedonia, Greece; [Hooman] Nakysa, Department of Pediatric Nephrology, Ali Asghar Children Hospital, Tehran, Tehran, Iran; [Mencarelli] Francesca, Department of Pediatrics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, BO, Italy; [Morello] William, Pediatric Nephrology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, MI, Italy; [Longo] Germana, Department of Women's and Children's Health, Azienda Ospedale Università Padova, Padua, PD, Italy; [Emma] Francesco, Department of Pediatric Subspecialties, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, RM, Italy; [Ruzgiene] Dovile, Clinic of Children's Diseases, Vilniaus Universitetas, Vilnius, Vilnius, Lithuania; [Wasilewska] Anna Maria, Department of Paediatrics and Nephrology, Uniwersytet Medyczny w Bialymstoku, Bialystok, PD, Poland; [Bałasz-Chmielewska] Irena, Department of Pediatric and Adolescent Nephrology and Hypertension, Gdanski Uniwersytet Medyczny, Gdansk, Pomeranian, Poland; [Miklaszewska] Monika, Department of Pediatric Nephrology and Hypertension, Jagiellonian University Medical College, Krakow, Małopolska, Poland; [Stańczyk] Małgorzata Barbara, Department of Pediatrics, Immunology and Nephrology, Instytut Centrum Zdrowia Matki Polki, Lodz, LD, Poland; [Sikora] Przemysław, Department of Pediatric Nephrology, Medical University of Lublin, Lublin, LU, Poland; [Litwin] Mieczyslaw S., Instytut "Pomnik - Centrum Zdrowia Dziecka", Warsaw, MA, Poland; [Morawiec-Knysak] Aurelia, Department of Pediatrics, Slaski Uniwersytet Medyczny w Katowicach, Katowice, SL, Poland; [Teixeira] Ana F., Pediatric Nephrology, Centro Hospitalar Universitário de São João, Porto, Porto, Portugal; [Miloševski-Lomić] Gordana, Department of Nephrology, University Children's Hospital, Belgrade, Belgrade, Serbia; [Prikhodina] L. S., Department of Inherited and Acquired Kidney Diseases, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russian Federation; [Rus] Rina R., Department of Paediatric Nephrology, Univerzitetni Klinični Center Ljubljana, Ljubljana, Slovenia; [Jilani] Houweyda, Service des Maladies Congénitales et Héréditaires, Université de Tunis El Manar, Hôpital Mongi Slim, La Marsa, Tunisia; [Melek] Engin, Department of Pediatric Nephrology, Çukurova Üniversitesi, Adana, Adana, Turkey; [Düzova] Ali, Department of Pediatrics, Hacettepe Üniversitesi, Ankara, Turkey; [Soylu] Alper, Department of Pediatric Nephrology, Dokuz Eylül Üniversitesi, Izmir, Turkey; [Candan] Cengiz, Division of Pediatric Nephrology, Istanbul Medeniyet University, Istanbul, Turkey; [Sever] Lale, Department of Pediatric Nephrology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; [Yilmaz] Alev Yavuz, Department of Pediatric Nephrology, İstanbul Tıp Fakültesi, Istanbul, Turkey; [Çi̇çek] Neslihan, Division of Pediatric Nephrology, Research and Training Hospital, Marmara Üniversitesi, Istanbul, Turkey; [Akinci] Nurver, Division of Pediatric Nephrology, Sisli Etfal Hospital, Istanbul, Turkey; [Mir] Sevgi, Department of Pediatric Nephrology, Ege University Medical School, Izmir, Turkey; [Dursun] Ísmail, Department of Pediatric Nephrology, Erciyes Üniversitesi, Kayseri, Kayseri, Turkey; [Tabel] Yilmaz Yilmaz, Department of Pediatric Nephrology, Inönü Üniversitesi, Malatya, Turkey; [Nalçacioǧlu] Hülya, Division of Pediatric Nephrology, Ondokuz Mayis Üniversitesi, Samsun, Turkey | en_US |
| dc.description.abstract | To test the association between bilateral nephrectomies in patients with autosomal recessive polycystic kidney disease (ARPKD) and long-term clinical outcome and to identify risk factors for severe outcomes, a dataset comprising 504 patients from the international registry study ARegPKD was analyzed for characteristics and complications of patients with very early (≤ 3 months; VEBNE) and early (4–15 months; EBNE) bilateral nephrectomies. Patients with very early dialysis (VED, onset ≤ 3 months) without bilateral nephrectomies and patients with total kidney volumes (TKV) comparable to VEBNE infants served as additional control groups. We identified 19 children with VEBNE, 9 with EBNE, 12 with VED and 11 in the TKV control group. VEBNE patients suffered more frequently from severe neurological complications in comparison to all control patients. Very early bilateral nephrectomies and documentation of severe hypotensive episodes were independent risk factors for severe neurological complications. Bilateral nephrectomies within the first 3 months of life are associated with a risk of severe neurological complications later in life. Our data support a very cautious indication of very early bilateral nephrectomies in ARPKD, especially in patients with residual kidney function, and emphasize the importance of avoiding severe hypotensive episodes in this at-risk cohort. © 2020, The Author(s). | en_US |
| dc.identifier.doi | 10.1038/s41598-020-71956-1 | |
| dc.identifier.issn | 2045-2322 | |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.pmid | 32994492 | |
| dc.identifier.scopus | 2-s2.0-85091924160 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.uri | https://doi.org/10.1038/s41598-020-71956-1 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12712/36384 | |
| dc.identifier.volume | 10 | en_US |
| dc.identifier.wosquality | Q1 | |
| dc.language.iso | en | en_US |
| dc.publisher | Nature Research subscriptions@nature.com | en_US |
| dc.relation.ispartof | Scientific Reports | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Severe Neurological Outcomes After Very Early Bilateral Nephrectomies in Patients With Autosomal Recessive Polycystic Kidney Disease (ARPKD) | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication |