Cryptococcal Meningoencephalitis Treated with Fingolimod in a Patient with Multiple Sclerosis

Abstract

Cryptococcus neoformans is an opportunistic fungal agent, which may cause infectiondepending on the state of immunity. The agent is especially prone to be localized in the centralnervous system. Fingolimod is an immunomodulatory drug that is used in the treatment of Multiple Sclerosis (MS). The use of this drug leads to a decrease in lymphocyte count and thus might result in the occurrence of the opportunistic infections like Cryptococcosis. In this article, we presenta MS patient that underwent fingolimod treatment and developed Cryptococcus meningoencephalitis.