Effects of intralesional long-acting corticosteroid injection in the experimental corrosive esophageal burns in the rats

Abstract

The effects of intralesional long-acting corticosteroid injection were investigated in rats with alkali-induced corrosive esophageal burns. In 30 rats, a standard esophageal burn was produced as described by Gehanno. The rats were then divided into three groups as follows: group I, rats with esophageal burns and parenteral antibiotic, group II, rats with esophageal burns and systemic corticosteroid and parenteral antibiotic, group III, rats with esophageal burns treated with antibiotic and intralesional long-acting corticosteroid. All animals were sacrified on the 21th day of experiment. Histopathologic evaluation was performed and collagen deposition in the submucosa, damage to the muscularis mucosa, damage and collagen deposition in the tunica muscularis were investigated for each group. Overall criteria for histopathologic evaluation in the group II were better than group I (p<0.05, p<0.05, p<0.05). As a result, intralesional long-acting corticosteroid injection may reduce extension of the new collagen synthesis into the tunica muscularis but its effect on stricture formation was not significantly better than systemic corticosteroid.