The acanthosis nigricans associated with gastric adenocarcinoma and neurofibromatosis

Abstract

We presented a case of acanthosis nigricans who exhibited an internal malignancy and neurofibromatosis. The patient who is 45 years old had pruritus and axillary and inguinal discoloration resembling Acanthosis nigricans. The diagnosis was confirmed by the biopsy of the skin. The tomographic, endoscopic, and histopathologic singular revealed a poorly differentiated gastric carcinoma of the corpus with café au lait macules, and skin-colored, pedinculated soft nodules. The histopathologic diagnosis of neurofibroma was confirmed by the excision of one of the nodules.